Page 710 - Clinical Immunology_ Principles and Practice ( PDFDrive )

684 ParT Six Systemic Immune Diseases

TRANSLATIONAL RESEARCH 9. Elliott MR, Ravichandran KS. Clearance of apoptotic cells: implications
in health and disease. J Cell Biol 2010;189(7):1059–70.
The challenge in the next decade is to continue elucidating the 10. Macedo AC, Isaac L. Systemic Lupus Erythematosus and Deficiencies of
underlying mechanisms of autoimmunity to improve diagnosis Early Components of the Complement Classical Pathway. Front Immunol
2016;7:55.
and treatment and enable more precise monitoring of these 11. Rai E, Wakeland EK. Genetic predisposition to autoimmunity–what have
diseases. The existence of distinct phases in the development of we learned? Semin Immunol 2011;23(2):67–83.
autoimmune disease provides an opportunity to identify patients 12. Bennett CL, Christie J, Ramsdell F, et al. The immune dysregulation,
at risk of developing tissue damage before this occurs and polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by
potentially to interdict the process before the amplification cycle mutations of FOXP3. Nat Genet 2001;27(1):20–1.
is established. Understanding natural mechanisms of regulation 13. Oliveira L, Sinicato NA, Postal M, et al. Dysregulation of antiviral
of disease amplitude, or in some circumstances, even disease helicase pathways in systemic lupus erythematosus. Front Genet
resolution, will provide important opportunities for therapy. 2014;5:418.
The role of the target tissue as an active participant, rather than 14. Sercarz EE, Lehmann PV, Ametani A, et al. Dominance and
a passive bystander, in the ongoing destruction will likely be crypticity of T cell antigenic determinants. Annu Rev Immunol
1993;11:729–66.
understood in molecular detail and provide novel approaches 15. Lanzavecchia A. How can cryptic epitopes trigger autoimmunity? J Exp
to decreasing the amplitude of amplifying cycles. The identifica- Med 1995;181(6):1945–8.
tion of the precise biomarkers of all these events requires 16. Darrah E, Rosen A. Granzyme B cleavage of autoantigens in
exceptional clinical phenotyping of patients early in the disease autoimmunity. Cell Death Differ 2010;17(4):624–32.
course, longitudinal analysis by centers of excellence that follow 17. Doyle HA, Mamula MJ. Posttranslational modifications of self-antigens.
up large numbers of patients with similar phenotypes over time, Ann N Y Acad Sci 2005;1050:1–9.
and effective coupling to basic laboratory enterprise. Critical 18. Engelhorn ME, Guevara-Patino JA, Noffz G, et al. Autoimmunity and
areas of future investigation relevant to diagnosis and therapy tumor immunity induced by immune responses to mutations in self. Nat
include clarification of the roles of genetic and epigenetic factors, Med 2006;12(2):198–206.
interactions between the innate and adaptive immune responses, 19. Shah AA, Casciola-Rosen L, Rosen A. Review: cancer-induced
Tregs, and focus on the target tissue and antigen contributions autoimmunity in the rheumatic diseases. Arthritis Rheumatol
2015;67(2):317–26.
to ongoing amplification. 20. Bernatsky S, Boivin JF, Joseph L, et al. An international cohort study of
cancer in systemic lupus erythematosus. Arthritis Rheum
Please check your eBook at https://expertconsult.inkling.com/ 2005;52(5):1481–90.
for self-assessment questions. See inside cover for registration 21. Cusick MF, Libbey JE, Fujinami RS. Molecular mimicry as a mechanism
details. of autoimmune disease. Clin Rev Allergy Immunol 2012;42(1):102–11.
22. Plotz PH. The autoantibody repertoire: searching for order. Nat Rev
Immunol 2003;3(1):73–8.
REFERENCES 23. Kawai T, Akira S. Toll-like receptors and their crosstalk with other innate
receptors in infection and immunity. Immunity 2011;34(5):637–50.
1. Davidson A, Diamond B. General features of autoimmune disease. In:
Rose NR, Mackay IR, editors. The autoimmune diseases. St Louis: Elsevier 24. Green NM, Marshak-Rothstein A. Toll-like receptor driven B cell
Academic Press; 2006. activation in the induction of systemic autoimmunity. Semin Immunol
2. Bizzaro N. Autoantibodies as predictors of disease: the clinical and 2011;23(2):106–12.
experimental evidence. Autoimmun Rev 2007;6(6):325–33. 25. Hall JC, Rosen A. Type I interferons: crucial participants in disease
3. Insel RA, Dunne JL, Atkinson MA, et al. Staging presymptomatic type 1 amplification in autoimmunity. Nat Rev Rheumatol 2010;6(1):40–9.
diabetes: a scientific statement of JDRF, the Endocrine Society, and the 26. Swiecki M, Colonna M. Unraveling the functions of plasmacytoid
American Diabetes Association. Diabetes Care 2015;38(10):1964–74. dendritic cells during viral infections, autoimmunity, and tolerance.
4. Dekkers J, Toes RE, Huizinga TW, et al. The role of anticitrullinated Immunol Rev 2010;234(1):142–62.
protein antibodies in the early stages of rheumatoid arthritis. Curr Opin 27. Gregorio J, Meller S, Conrad C, et al. Plasmacytoid dendritic cells sense
Rheumatol 2016;28(3):275–81. skin injury and promote wound healing through type I interferons. J Exp
5. Arbuckle MR, McClain MT, Rubertone MV, et al. Development of Med 2010;207(13):2921–30.
autoantibodies before the clinical onset of systemic lupus erythematosus. 28. Guiducci C, Tripodo C, Gong M, et al. Autoimmune skin inflammation is
N Engl J Med 2003;349(16):1526–33. dependent on plasmacytoid dendritic cell activation by nucleic acids via
6. Kawasaki T, Kawai T, Akira S. Recognition of nucleic acids by TLR7 and TLR9. J Exp Med 2010;207(13):2931–42.
pattern-recognition receptors and its relevance in autoimmunity. 29. Casciola-Rosen L, Nagaraju K, Plotz P, et al. Enhanced autoantigen
Immunol Rev 2011;243(1):61–73. expression in regenerating muscle cells in idiopathic inflammatory
7. Cutolo M. Autoimmune polyendocrine syndromes. Autoimmun Rev myopathy. J Exp Med 2005;201(4):591–601.
2014;13(2):85–9. 30. Mammen AL, Chung T, Christopher-Stine L, et al. Autoantibodies against
8. Anderson MS, Venanzi ES, Klein L, et al. Projection of an immunological 3-hydroxy-3-methylglutaryl-coenzyme A reductase in patients with
self shadow within the thymus by the AIRE protein. Science statin-associated autoimmune myopathy. Arthritis Rheum
2002;298(5597):1395–401. 2011;63(3):713–21.