Page 750 - Clinical Immunology_ Principles and Practice ( PDFDrive )

CHaPtEr 52 Rheumatoid Arthritis 721.e1

MUL t IPLE-CHOICE QUES t IONS

1. Which of the following statements is correct regarding D. The shared epitope refers to a common sequence in a
autoantibodies in rheumatoid arthritis (RA)? subset of major histocompatibility complex class II alleles.
A. Antibodies to citrullinated peptides are highly specific for E. The shared epitope causes rheumatoid arthritis.
rheumatoid arthritis. 3. Which of the following characteristics are NOT typical features
B. Citrullination is found only in joint tissues. of individuals at high risk of developing RA?
C. Citrullination requires the presence of the amino acid A. A family history of RA
asparagine. B. Low body mass index (BMI)
D. Citrullination generates antigenic epitopes by posttrans- C. Inflammatory joint pain
lational modification of pathogen-derived peptides. D. A history of tobacco exposure
E. Antibodies to citrullinated peptides are generated after E. Low alcohol intake
onset of disease.
2. Which of the following statements is correct regarding the
shared epitope?
A. The shared epitope refers to a common bacterial antigen.
B. The shared epitope refers to a common viral antigen.
C. Antibodies to the shared epitope are characteristic for RA.