Page 935 - Clinical Immunology_ Principles and Practice ( PDFDrive )

CHaPter 66 Multiple Sclerosis 902.e1

MUL t IPL e -CHOIC e QU e S t IO n S

1. The etiology of multiple sclerosis is believed to be: 3. To make a diagnosis of relapsing remitting MS it is critical
a. a viral infection of the central nervous system to demonstrate:
b. an autoimmune disorder mediated by myelin-reactive a. Dissemination of lesions in time
lymphocytes b. Dissemination of lesions in space
c. a primary neurodegenerative disorder c. Immunoglobulin synthesis in the central nervous system
d. a toxic encephalopathy d. Worsening of symptoms with increases in core body
temperature
2. The mechanism of action of disease modifying therapies
currently used to reduce MS relapse rates is: e. a and b
a. Blockade of lymphocyte trafficking to the central nervous
system
b. Depletion of lymphocytes
c. Inhibition of T cell proliferation
d. Inhibition of pyrimidine synthesis
e. All of the above