Page 179 - Clinical Hematology_ Theory _ Procedures ( PDFDrive )

8 Leukocytes: T e Granulocytic and

CHAPTER Monocytic Series

KEY TERMS

agranulocytosis granules myelocyte

azurophilic granulocytic kinetics neutrophil

Auer Rods in am m ation neutrophil extracellular traps (NETs)
basophils leukoerythroblastosis opsonins
Charcot-Leyden crystals macrophages opsonization

chem otaxis marginating pool phagocytosis

circulating pool Mast cells proliferative com partm ent
colony-stim ulating factor maturation-storage compartment prom yelocyte
diapedesis monocytes segm ented neutrophils

eosinophils mononuclear phagocyte system

etravasation myeloblast

LEARNING OUTCOMES

Introduction Normal maturational characteristics of

■ Name the source of the cellular elements of the blood. granulocytes

■ Name the three major categories of the cellular elements of the ■ Describe the nuclear and cytoplasmic characteristics of the neu-

circulating blood. trophils, eosinophils, and basophils throughout the maturation

process.
Granulocytic series: production of neutrophils, Explain the appearance and etiology of the various morphological

eosinophils, and basophils ■ abnormalities encountered in mature granulocytes.

Brie y explain the general factors related to the development of ■ Define terms associated with an increase and decrease in

multipotential progenitor cells into speci c leukocyte cell lines. granulocytes.

Compare growth factors and inhibitory factors in granulocyte ■ Explain the term, shift to the left

development. Describe the abnormalities associated with mature granulocytes in

Granulocyte sites of development and body uids.

maturation Leukocyte surface markers

■ List each type of immature neutrophil found in the proliferative com- ■ De ne the term leukocyte surface marker.

partment of the bone marrow along with the percentage of each ■ Name one technique for identifying cell surface markers.

Cite the approximate time spent in each developmental stage of ■ Name the system for identi cation of cell surface markers.

neutrophils in the proliferative compartment.

■ List each type of neutrophil found in the maturation-storage com- The monocytic-macrophage series

partment of the bone marrow along with the percentage of each. ■ Associate the various terms for macrophages depending on their

Cite the approximate time spent in maturation-storage compartment anatomical site.

phase. Discuss the differentiation of monocytes and macrophages from the
multipotential stem cell.
Distribution of neutrophils, eosinophils, and ■ Compare the bone marrow maturation of the monocyte with that of

basophils the neutrophils.

Describe the chemical factors and cellular characteristics that per- ■ Describe the general functions of macrophages.

mit neutrophils to exit the bone marrow and enter the peripheral Compare the life span of monocytes and macrophages in the circu-

circulation. lating blood and tissues.

■ De ne the terms marginating and circulating pools. ■ Describe the nuclear and cytoplasmic characteristics of the mono-

■ Discuss the length of time the neutrophils, eosinophils, and baso- cyte as it develops.
phils spend in each marginating and circulating pool.

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