Page 181 - Clinical Hematology_ Theory _ Procedures ( PDFDrive )

CHAPTER 8 ■ Leukocytes: The Granulocytic and Monocytic Series 165

mm - HSC Progenitor cells Stem cell pool

m x m . 0.1%–0.2%

Myeloblasts 1% 15 hours
Grow th Factors Promyelocytes

Mitotic pool 3% 24 hours
F colony-stimu- Myelocytes 5–7 days

lating factor (CSF) k . T 12% Post Mitotic

CSF k , m m

m

(myeloid) m -m

. I

m , CSF m , A

m .

Grow th Inhibitors

Metamyelocytes
C m (CDD) k 45%

-m - m
(GM-CFC). V Band form Segmented

m , m m neutrophils neutrophils
m -β, m 35% 20%

-α m -β, m mm -
- , . B

FIGURE 8.1 B m m m . A. P .

GRANULOCY E SI ES OF DEVELOPMEN B. M - ( ).

AND MA URA ION
m m m . T

T m , , - x m %, %, %, -

, , . T m m -
granulocytic kinetics . T , m m q m .

, m T - - . I
m . T m - m m m

, m , m , m m - . E
m . M . m . , m

W - m , - - , x m .
m k (CFU-GEMM) - N k m m

- m , -m m m — m , -
(CFU-GM) , m mm , . M m -

m ; m - m m m
m m m m m . I ,

m k m
m ’ m m (F . . A). T . I ,

mitotic pool DNA . I GM-CSF G-CSF
. mm ,

T myeloblast -
. M x m % k .

m . T x -
m . T x , promyelocyte, DIS RIBU ION OF NEU ROPHILS,

x m % m . T EOSINOPHILS, AND BASOPHILS
. T myelocyte x m -

, x m % T neutrophils m m
x . T m m metamy m m x . C -

elocyte . . O m m (F . . ) m m -
, m

proliferative phase m . m , m m . S m
F , mat -

uration storage compartment (F . . B). T m m - k . C -

m m m z m - m . T