Page 262 - Clinical Hematology_ Theory _ Procedures ( PDFDrive )

246 PART 4 ■ Erythrocyte Disorders

m m m - x mm m
. T m m k .

m m . I , m L ’ m

m x m -

m m . F , m m m k m -

m m . A -INF x q

. I m m , m m m k .

k m m m k L m k -

k m , m , m m m

. m . M m m k ’ m

I m q m , m - m q m

m mm m , - m m m .

. T

( . ). T m Clinical Features

k , m A q m z m -

m .

A m mm m

m m , , . I mm -
. T m m ,
m . A ,

x m m m m

m m . T m m

m m m m ; m m ,

m m ’ m m m m , m m -

m m m . m . S m m .

B m m R - m

m x m , q m m k -

m - q m m -

m (A G) . INF-α NF , mm

m . P x m m (PNH)

m . T x m % , m

INF-α NF m m - m (MDS) m k m (AML)

m . m x m %

T mm

m m m m . T m
m mm
. I m m m . O

CD m - m m k m .

II m HLA-DR

, m Laboratory Findings

k J . N ,

A m m

mm m m m

TABLE 13.2 Phases of Aplastic Anemia

Phase 1: Onset of disease After an initiating event (e.g., viral infection), the hematopoietic compartment is destroyed by the

immune system.

Small numbers of surviving stem cells support adequate hematopoiesis for some time, but even-

tually, the circulating cell counts become very low and clinical symptoms appear.

Phase 2: Recovery Either a partial response or a complete response can occur, at least initially, without increased
numbers of stem cells.

In a minority of patients, the primitive cell compartment appears to repopulate over time by the

process of self-renewal of stem cells.

Phase 3: Late disease Years after recovery, blood counts may fall as a relapse of pancytopenia occurs, or an abnormal

clone of stem cells may emerge, leading to a new diagnosis of PNH, MDS, or AML.