Page 260 - Clinical Hematology_ Theory _ Procedures ( PDFDrive )

244 PART 4 ■ Erythrocyte Disorders

BONE MARROW FAILURE SYNDROMES Disease Easily Confused w ith
TABLE 13.1
Aplastic Anemia

B m m z

q m Constitutional* Characteristics

, , / m

. B m Fanconi’s anemia Expressed in young patients,

q . physical anomalies

Dyskeratosis congenita Expressed in young patients,

General Characteristics of Bone Marrow physical anomalies

Syndromes Acquired

C m m Aleukemic leukemia Very young or very old patients,

, pancytopenia, constitutional blasts in buffy coat and bone

aplastic anemia , marrow spicules

m x m m . S m Large granular Older patients, neutropenia

m j RBC, WBC, lymphocytosis

. I , Myelodysplasia Older patients; bone marrow has

m m normal cellularity or hypercellular

m m m Myelo brosis Hepatosplenomegaly, leuko-

m k m . erythroblastic appearance on

M m m peripheral blood smear

m , , m

m . B m - Paroxysmal nocturnal RBC hemolysis

m m hemoglobinemia (PNH)

m (MDS ) ( C XX) *Phenotypic abnormalities may be subtle or absent.

x m m (PNH) (

C )

m , m . m . I

m

Hematology Laboratory Findings in Bone m x .

Marrow Failure Syndromes A m
(iatrogenic) m
P m . . A m

U x m m x m

m , m m . C m j

x . I m , m m - q m , -

m . M m m k , - m DNA m . D -

m . E m m

m F mm . C m % % (B x . ). I z

m x , x m , m m k - m m . I -

, -P -H , — m m , ,

m , m m - - - — m

m , m . mm , -

m .

ACQUIRED APLAS IC ANEMIA I

. B z z
Aplastic anemia P E .

m m . A - . I k

m , m , q . I

. S m . A m ( m

m ( . ). I , - m )

m m . A

Etiology Benzene

M q m q P mm - q m

mm -m m . M x x