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CHAPTER 14  ■  Disorders of Iron Metabolism and Heme Synthesis                                      261





                               Inges tion and abs orption                                        Trans port                                    Us e or s torage                                       Excretion





                          Iron from                                                                                                   Body cells                                                   Exfoliation
                          food                                                                                                                                                                     of epithelial

                          intake                                                                                                                                                                   cells or bile,

                          Fe  +++                                                           Fe  transferrin                           Storage of                                                   urine, feces
                                                                                                +
                                                                 Stomach                    Plasma iron pool                          ferritin and
                                                                                                                                      hemosiderin

                                                                                                                                      in the

                                                                                                                                      mononuclear

                                               Duodenum                                                                               phagocyte
                                                                                                                                      system






                                                                                                                                      Hemoglobin                      RBCs
                                                   Jejunum




                                                                                                                                      Hemoglobin                                                   RBC loss

                                                                                                                                      catabolism                                                   Menstruation
                                                 Ileum







                   FIGURE 14.2  I                      .





                    x                                                                     .  A                                                              ,                 m

                       m           m             x m           %         %                                                                                       m                                         . W         -

                         k                     m  /  .                                                                                            ,                  -                                               ,     -

                        M                                   m                                   m        -

                                         ,                  m                      .                 ,                                                                                            -                      -

                                         ,                          .                                                                                      ,                                            m                   -

                                                    m                                        m                                                                                            m        . T

                                   m                  .                                                                                                                                                                   -

                        T                                         m     m  mm                                                                                  ,                                 m     m

                                                                                                                                                                                                                    . T

                          m  m                                          ,                                                      m          m

                                           . T                        k                                                                                                                                                     ,

                                                       -          m     x                              -                       m  k            f                                               -                       -

                       . U             m            m           ,                 q                   -                                          m                               . S                                m-

                           m            m        q                                             . C                             m

                                                     m                                                                                        ,                                         m

                                                                                               ,                                     -                                                                           .

                                                                                                                                    I                   m                                -           m     x         -

                      q      m      ,                       m                         z                                                                                            m  m

                           m                                                         . T                    -                               . I                 q                        ,

                                                                                                                                                             m             m                                          .

                                                     mRNA                                                                           A        m                                                    ,                  m-

                                                                                  q     m     . I     -                                                                                m           . S

                                                                       m                         ,                                                                        m      m                       . M          -

                                     m                     -                          -                   .                                                                            m                ,

                        C                                                                                                         q                            . I          m                                       -

                                             m                 m      ,                                                                 ,          m                                                                    -

                                                          k                           k . C                                                   m            . I            k         m

                                                                                         ,                                                                 k                                                      .

                                                                                  .                                                 T                                               m

                        C                                                                                                             m. I                          ,                                            m

                                                   ,                                                                              m       m        GI         ,

                                                                      m        . W                                                                                . A         m

                              ,       m            (SF)                                                                            m                         ,                                     m                  .
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