Page 278 - Clinical Hematology_ Theory _ Procedures ( PDFDrive )

262 PART 4 ■ Erythrocyte Disorders

Pathophysiology - m . I m

A IDA m . T q - . H , -

m

m m m . E m q . P m

( . ). T m - .

■ S : P —

■ S : L — Chronic Blood Loss

■ S : A m — C q
m x GI , m

m m -

m . I m m x

Clinical Signs and Symptoms , m

. R RBC
T - . T m m

k .

m m , , / k . A m

P m m IDA. T m m m . A , m m -

m m m , m m . G ,

. A m m , m m -

m m . T WBC

m . P IDA m . P mm

x m , , ,

m . k .

IDA m m -

m m . C , m Genetics and Iron De ciency

U S m

f , % - G m

m , % IDA. m m. T

P , m - m m (SNP) m -

( . ., , k , k, ), m

TABLE 14.2 Sequential Phases of Iron De ciency *

Stage 1 Stage 2 (Latent) Stage 3 (Anemia) Decrease in

(Prelatent) Decrease in Iron Circulating Red Blood Cell

Decrease in Available for Parameters and Decrease in

Storage Iron Erythropoiesis Oxygen Delivery to Peripheral Tissues

Bone marrow iron stores Decreased Absent Absent

Serum Iron

Serum ferritin level Decreased <12 µg/L <12 µg/L

Transferrin saturation Normal <16% <16%

Free erythrocyte protoporphyrin, Normal Increased Increased
zinc protoporphyrin

Serum transferrin receptor Normal Increased Increased

Reticulocyte hemoglobin content Normal Decreased Decreased

Hemoglobin Normal Normal Decreased

MCV Normal Normal Decreased

Clinical signs and symptoms Present

* The changes in laboratory measurements are progressive.

MCV mean corpuscular volume.
,
From Greer JP, et al. Wintrobe’s Clinical Hematology, 11th ed, Philadelphia, PA: Lippincott Williams & Wilkins, Table 28.2 Stages in the Development of Iron

De ciency, 2004:989.