Page 282 - Clinical Hematology_ Theory _ Procedures ( PDFDrive )

266 PART 4 ■ Erythrocyte Disorders

B Iron loss Increased erythroid demand Fe
1–2 mg/day Hypoxia Inflammation

Bone marrow
~300 mg – +

D HFE/TfR1

TfR2
HJV/sHJV
Liver
20–25 Fe – Tf

mg/day ~3 mg
Erythrocytes
~1800 mg Iron uptate +
1–2 mg/day

C

A

Hepcidin
Macrophages
~600 mg

FIGURE 14.5 P x . T x k m
m . N

x x m . T m m j . O

m . Im , m
, m k m m

. H , , m , β- – k ,

m x m -

m . A q , m

. H x , mm m ,
m , x x HFE, RF , HJV .

I HFE-, R -, HJV- HH ( m m ),

, . A, B, C, D
m m. (R m S k DW, . H m m : m x

, Clin Chem, ( ): , ; F , m )

H H m m . Ex

x k m

m , x m , m j j m (MPS). B k

. -

H m m m m m

m m. H m .

m m m m m : R m

m x -
. D m m m
x - (HIF) m , , m m

- (IRP )
. R m m m k .
H , m
. R m
,

M , x , -

, k m . H m

. W , q m m

, m m . H .

m q m I m -

. T m - - m m -

, , q mm k

z . m . H