Page 281 - Clinical Hematology_ Theory _ Procedures ( PDFDrive )

CHAPTER 14 ■ Disorders of Iron Metabolism and Heme Synthesis 265

R . A - AOI/ACD

- , , , , -

m R, m . O m m ,

m . A , m j , m , m , m -

R IDA m m (SLE), m , . A m -

AOI ACD . T R, j m m

x, m - . A m -

x m m AOI/ACD, x m m

m ACD. q .

R, m m m - -

, - Pathophysiology

- . T , AOI/ACD hypoproliferative anemia m -

z . A -

. T m ( m ,

m . A m ),

R MCH m m j

. m m .

F ; R M m m m

. R mm m ( . ).

.

T m R Hepcidin

m m . A - T x -

: m , hepcidin, (F . . )

. B z AOI/ACD. T

m ACD

mm , - m , . B m m

ACD m IDA. I IDA x m . H , m - m

ACD, - m , k m

. W SF . E , mm

µ /L k mm m - -

, m m .

x . I , x

:

m m , m . A

m ; , m

m IDA - m (BMP) m x.

.
. A x
IL- –m mm .

NOTE: This is a good time to review the de nitions of Key

Terms found in the Glossary and ash cards on .

Also, complete Review Questions related to the preceding

content. Mechanisms Associated w ith

TABLE 14.5 Anemia of In ammation/

Malignancy
ANEMIA OF INFLAMMA ION OR ANEMIA

OF CHRONIC DISORDERS/DISEASES
1. Increased hepcidin production

Etiology 2. Alterations in production of proin ammatory cytokines;

Anemia of in ammation or anemia of chronic disorders/diseases interleukins (IL-1), (IL-6); tumor necrosis factor alpha

(AOI ACD) m m IDA. (TNFα); interferons

R m AOI/ACD 3. Hemolysis (drug induced, microangiopathic, autoimmune)

, , , k . T 4. Effects of chemotherapy

m m mm m 5. Nutritional de ciencies

mm , , m ,

m mm . A x m 6. Blood loss