Page 308 - Clinical Hematology_ Theory _ Procedures ( PDFDrive )

Principles o Blood Collection and
16 Hemolytic Anemias

CHAPTER Processing

KEY TERMS

acquired hem olytic anem ia glucose-6-phosphate dehydrogenase isoim m une hem olytic anem ia

autoim m une hem olytic (G6PD) methemoglobin reductase de ciency
anem ia hem oglobinuria paroxysm al cold hem oglobinuria

com plem ent hem olytic anem ias paroxysm al nocturnal
extravascular hem olysis intravascular hem olysis hem oglobinuria

extrinsic hem olytic anem ias intrinsic hem olytic anem ia pyruvate kinase de ciency

LEARNING OUTCOMES

Hemolytic anemias ■ Describe hemolytic disease of the fetus and newborn as an example

■ De ne the term hemolytic anemia. of isoimmune hemolytic anemia.

■ Name at least three categories of intrinsic versus extrinsic hemo- Compare immediate and delayed types of hemolytic transfusion
lytic anemia reactions.

■ Name two medical conditions that can be the cause of hemolysis.

The role of complement in hemolytic anemia Describe the physiology and typical laboratory ndings in hemolytic

■ Discuss the action of complement in producing hemolysis. anemia.
Complement-mediated disease

Inherited hemolytic anemias ■ Characterize the etiology of paroxysmal nocturnal hemoglobinuria.

■ Name two categories of inherited hemolytic disorders ■ Explain the physiology of paroxysmal nocturnal hemoglobinuria.
Explain the basis of structural membrane defects. ■ Describe the clinical signs and symptoms, laboratory ndings, and

■ Name and discuss ve types or varieties of membrane defects. treatment protocol of PNH.
Explain the consequences of erythrocytic enzyme de ciency in two ■ Brie y describe the characteristics of cold agglutinin disease.

defects.
Case studies

Analyze the patient history, clinical signs and symptoms, and labo-
Acquired Hemolytic anemias ratory data for the stated case studies, answer the related critical

■ Name and brie y explain three categories of acquired hemolytic thinking questions, and conclude the most likely diagnosis.
anemia.

■ Name four mechanisms of drug-induced hemolytic anemia.

■ Discuss immune mechanism related to acquired hemolytic NOTE:
anemia. ■ indicates MLT and MLS core content

■ Compare various types of autoimmune hemolytic anemia (AIHA). indicates MLT (optional) and MLS advanced content

HEMOLY IC ANEMIAS m m ( m ),

m m , z m . O

T mm m hemolytic anemias - z m m m

m m -

■ I q

m . ■ I x

H m m m ■ Imm mm

m m x m - I m m m

m m . I m . W

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