Page 309 - Clinical Hematology_ Theory _ Procedures ( PDFDrive )

CHAPTER 16 ■ Hemolytic Anemias 293

m HE ROLE OF COMPLEMEN IN

m , m HEMOLY IC ANEMIA

.

M m m m , Complement m m m-

m m , m -

. T - , , . T m m

m , m m , - m m -

m . H m m m m m m - .

m - , - A m m ( F . . ) m

. m m :

Clas s ical Lectin Alternative

B

B 3 H 0
Ab 1q MBL 2

"Tick-over"
D
bacteria Initial
bacteria Ba Bb 3 C Convertase
3
1r
Ab 1q B 3

1s 3a
D B 3b

bacteria
1r 4
C Esterase 1q 2 Ba
1
1s
Bb 3b

3a
2b P
4a 2a P
4b 3b Bb 3b C Convertase
3
C Convertase
3

P
2a
C Convertase 3b 3b 4b 5 Bb 3b 3b 3b C Convertase
5
5

6 5a

7 5b
MEMBRANE ATTACK COMPLEX

8 6 5b
7

6

8 7 5b

9

6
8 7 5b

MAC

6
8 7 5b

FIGURE 16.1 C m m .