Page 322 - Clinical Hematology_ Theory _ Procedures ( PDFDrive )

306 PART 4 ■ Erythrocyte Disorders

P m

m - - BOX 16.5

m .

. B x . , ,

m m - Differential Testing in Hemolytic Anemias

m m A ,

.

B m x m

C
NOTE: This is a good time to complete Review Questions

related to the preceding content. G PD
M j ( )

L

COMPLEMEN -MEDIA ED DISEASE

T m

x m m (PNH), m m . W m m
m m m ( HUS) m - , m m ,

m m (HUS), m , m . C -
(CAD), CD . C m PNH m

m m -m . m m .
x m . PNH x m m ,

m , m . I m

Paroxysmal Nocturnal Hemoglobinuria z m ( x m )

- ( ) ( m -
Etiology ). S m PNH m

PNH q m m m m m

x m m - m .

GPI, m

m z Epidem iology

m m . - m

PNH , q , m . A x m % % -

m x m m - m m k m .

m q m m T m ( ,

X- m m , PIGA. T PIGA , ). M .

m x m , q S - m m .

GPI . T

, m m , Pathophysiology

CD CD . T m m M m PIGA -

m

Clinical Manifestations of
Typical Pro le of Quantitative TABLE 16.5 Complement-Mediated Diseases

TABLE 16.4 LABORATORY Findings in

Hemolytic Anemias PNH Hemolysis, Thrombosis

Test Result HUS (typical) Hemolysis, thrombocytopenia,

renal failure

Hemoglobin, hematocrit, RBC Decreased HUS (atypical) Hemolysis (extravascu-
count
lar), thrombocytopenia,
Serum haptoglobin Decreased thrombosis, renal failure

Red blood cell survival ( Cr) Decreased CAD Hemolysis (extravascular and
51

Lactic dehydrogenase (LDH) Increased intravascular)

isoenzymes (LD and LD) TTP Hemolysis, thrombocytopenia,
1
2
Bilirubin (total) Usually increased thrombosis

Antiglobulin test Positive or negative Congenital CD59 de ciency Hemolysis