Page 319 - Clinical Hematology_ Theory _ Procedures ( PDFDrive )

CHAPTER 16 ■ Hemolytic Anemias 303

TABLE 16.3 Comparison of Warm and Cold Autoimmune Hemolytic Anemia

Warm AIHA Cold AIHA

Optimal temperature of reactivity 37°C 4°C

Immunoglobulin class IgG IgM

Complement activation ± +

Site of hemolysis Extravascular Intravascular

T m m .

: m k m , I RBC m

, m - , m

m . , -

z m . L
Etiology x ,

T m m HDFN q j .

m I G B m x m

I I G . A -A -B m -

m - m.

m (I M) , q I G m m

HDFN ABO m Diagnostic Evaluation

m . A -A -B A

. H HDFN: T

-A, -B I G O m ABO

m HDFN. ■
■ R

Epidem iology ■ S ; -

T HDFN m ABO - Am ( )

m . T m q m ■ S m

ABO m m O ■ D

A B, A. ■ P m

U , R -D ■

m q m m HDFN. ■ F m K -B k ( m
)
A -D x m % -

ABO HDFN. S m m - T m -

m m mm z D , ’ m

q HDFN -D m .

.
Prevention

Signs and Sym ptom s I , R I G m U

A I G, mm S . S m , HDFN

, m m -D m , m m -

. m -D

O m m - m . A R - m

, R I G, R

. H m k , D -

m m z - m .

. B m , m - Hem olytic Transfusion Reactions

- .

m RBC , , , Im m ediate Transfusion Reactions

m - T m mm m

. I RBC m , ABO – m

x m m , m . I - x m

m , m