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390            PART 6  ■  Neoplastic Disorders




                                             m. Auer rods                m                         -                       Acute Promyelocytic Leukemia (FAB M3)

                                        .  T                          m

                  m               . G      ,                   , m                    (                                    I                  m                     k  m    (APL),       m

                                )                                                           . S  m                                                           ,           m                                    x -

                                            m                 m                            m                               m              m        . T             x m      m     :   m                   :  .

                       . D                                ,    m        m                m                                      S                                          A  RA                     m

                         . A                                             m                                                      m z                     A  RA-                 m     ,            m

               m                     (    q          P        -H  ë         m     ).  A       m                               m                                                                  %,            -

                                m                       . M                                                                          -                                                    %.  T            m

                               %                                                                        .                        m                    m            m                       -                   -
                                                                                                                                                                                      ,


               Acute Myeloid Leukemia (FAB M2)                                                                                                  m          m                              m                k  -
                                                                                                                           m    (CML).

               T   WHO            m                                      m

                    k  m           m              . T    FAB M       m          k  m                                       Clinical Signs and Sym ptom s

                                                m        -                     .  T     m                                  F                     m     m                                             ,     m  -

                                                     ;              ,          x m             %                                  ,                                       mm    .  H         m        ,            -

                                                                               . T            x m                          m        ,             m                                                q         .  M

               m     :   m                   .  :  . S                 .   m        .                                                                 m                                         k  m

                                                                                                                                                                                                 ,                   ,
               Clinical Signs and Sym ptom s
                                                                                                                                        k .

               H  m              m                                                    ,          x  ,

                                          ,                                   mm                  m  -                     Laboratory Data

                  m . H         m        ,           m        ,           m                                                L                              m            m                             FAB M

                                    q         .
                                                                                                                                  .  A    m                   m                                               m


               Laboratory Data                                                                                                   .              k                                 m                         -
                                                                                                                           k                     k            . L    k                           q         .
               A    m                 m                                           m             .                               P   m                                     m                           (F   .     .  ).

               L    k                    mm               ,                                                                T         m                 m                                  ,  m                   ,

                            k                       x                     ×     /L.                                                                                 .  C        ,                    z

                    M                          m                                              m                                                                                        m. T

               (F   .     .  ). T                                                                                             m        -                                                    m                  -

                  m         m                                                         m      .                                . T                        m                                 ,

               T                m                                                 m                -                                    k              . M                                        m

                  m        z  m  -       azurophilic granules. A                       m-                                                            m      m                                                 m

               m               . M                                                                                          m     A            . A                                               m

                             .
                                                                                                                                                                    (DIC) (      C               )        m-

                                                                                                                           m         APL.

                                                                                                                                C                      , M                      z                                     -

                                                                                                                                                                              m     m                    ,

                                                                                                                                                                       PML

                                                                                                                                         α (RARα).

                                                                                                                                M                    (                     )                                m  -

                                                                                                                                             k  m     (  PML-M    )  (F   .      .  )

                                                                                                                             %       %       PML. I      m                                  PML-

                                                                                                                           M              m                                                  k  m

                                                                                                                                                                                      m

                                                                                                                                                                                                          PML.

                                                                                                                           M                      ,          m                  m      m

                                                                                                                                ,                       m                                                           -

                                                                                                                                          . O                       x        A            . T

                                                                                                                                      PML/RARα

                                                                                                                            PML               m                  %     AML-M


               FIGURE 21.5  A        m                k  m    M              m                                             PML/RAR                                . T

               A            . (R                  m M  C             KD. Clinical Laboratory                               PML/RAR
               Medicine,            , P                  , PA: L               W      m  & W  k    ,                       m          m

                    ,             m        .)                                                                               -                   -                            .
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