Page 734 - Clinical Hematology_ Theory _ Procedures ( PDFDrive )

F Interleukins

APPENDIX

Summary of Interleukins (ILs)

Name Source Target Blood Cells Function

IL-1 B cells, monocytes, dendritic T helper cells Costimulation

cells. B cells Maturation and proliferation

Appears to in uence dif- NK cells Activation

ferent progenitor cells indi- Macrophages In ammation

rectly in hematopoiesis. It

may act in synergy with IL-3,

M-CSF, G-CSF, and GM-CSF

to stimulate cells.

IL-2 Th1 cells Activated T cells and B cells, In uences the proliferation and regulation of

NK cells, macrophages T cells, B cells, natural killer (NK) cells, and

monocytes. It acts on activated B cells as a

growth and differentiation factor.

IL-3 Activated Th3 cells, mast Hematopoietic stem cells Promotes the growth of early hematopoietic cell

cells, NK cells, endothelium, Mast cells lines (e.g., proliferation of CFU-GEMM, CFU-M,

eosinophils CFU-Meg, CFU-Eo, and CFU-Bs colonies from

bone marrow). IL-3 acts with M-CSF to stimulate

proliferation of monocytes and macrophages. It

also stimulates granulocyte, monocyte, eosino-

phil, and mast cell production.

Growth and histamine release

IL-4 Th2 cells, just activated Activated B cells Proliferation and differentiation, IgG1 and IgE

naive CD4 cell, memory T cells synthesis
+
CD4 cells, mast cells, Proliferation
+
macrophages

Interacts with G-CSF to

proliferate myeloid progeni-

tor cells.

IL-5 Th2 cells, mast cells, eosino- Eosinophils Stimulates eosinophil colony production and

phils B cells interacts with GM-CSF and IL-3 in eosinophil

induction.

Differentiation, IgA production

IL-6 Macrophages, Th2 cells, B Activated B cells Differentiation into plasma cells

cells, astrocytes, endothe- Plasma cells Antibody secretion

lium HSCs Differentiation

T cells, others Induces acute phase reaction, hematopoiesis,

differentiation, in ammation

IL-7 Bone marrow stromal cells Pre/pro–B cell, pre/pro–T Differentiation and proliferation of lymphoid

and thymus stromal cells cell, NK cells progenitor cells, involved in B, T, and NK cell

survival, development, and homeostasis,

↑ proin ammatory cytokines

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