Page 735 - Clinical Hematology_ Theory _ Procedures ( PDFDrive )
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APPENDIX F ■ Interleukins 719
Summary of Interleukins (ILs) (continued)
Name Source Target Blood Cells Function
IL-8 Macrophages, lymphocytes, Neutrophils, basophils, An in ammatory cytokine that is chemotactic
epithelial cells, endothelial lymphocytes for both neutrophils and T cells. It is a potent
cells stimulator of neutrophils, and it activates the
respiratory burst and the release of both spe-
ci c and azurophilic granular contents.
IL-9 Th2 cells, speci cally by T cells, B cells Acts as a potent CD4 T lymphocyte growth
+
CD4 helper cells factor. In addition, it has been demonstrated
+
to support growth of BFU-E.
IL-10 Monocytes, Th2 cells, CD8 Macrophages Cytokine production
+
T cells, mast cells, macro- B cells Activation inhibits Th1 cytokine production
phages, B cell subset Mast cells (IFN-γ, TNF-β, IL-2)
Th1 cells Stimulation
Th2 cells
IL-11 Bone marrow stroma Bone marrow stroma Multifunctional regulator of hematopoiesis
IL-12 Dendritic cells, B cells, Activated T cells Differentiation into cytotoxic T cells with IL-2,
T cells, macrophages NK cells ↑ IFN-γ, TNF-α, ↓ IL-10
↑ IFN-γ, TNF-α
IL-13 Activated Th2 cells, mast Th2 cells, B cells, Stimulates growth and differentiation of
cells, NK cells macrophages B cells (IgE), inhibits Th1 cells and the produc-
tion of macrophage in ammatory cytokines
(e.g., IL-1, IL-6), ↓ IL-8, IL-10, IL-12.
IL-14 T cells and certain malignant Activated B cells Induces growth and proliferation of B cells,
B cells inhibits Ig secretion
IL-15 Mononuclear phagocytes T cells, activated B cells Induces production of natural killer cells
(and some other cells),
especially macrophages fol-
lowing infection by virus(es)
IL-16 Lymphocytes, epithelial CD4 T cells (Th cells) CD4 chemoattractant, increases the mobility
+
+
cells, eosinophils, CD8 of CD4 T cells
+
+
T cells
IL-17 T helper 17 cells (Th17) Epithelium, endothelium, ↑ In ammatory cytokines
other
IL-18 Macrophages Th1 cells, NK cells Induces production of IFN-γ,↑ NK cell activity
Acts as a synergist with
IL-12 in some of its effects
IL-19 — Regulates the functions of macrophages;
suppresses the activities of Th1 and Th2
IL-20 Biological activities similar Regulates proliferation and differentiation of
to IL-10 keratinocytes
IL-21 Activated T helper cells, All lymphocytes, dendritic Costimulates activation and proliferation of
NKT cells cells CD8 T cells; augments NK cytotoxicity; aug-
+
ments CD40-driven B cell proliferation, dif-
ferentiation, and isotype switching; promotes
differentiation of Th17 cells
IL-22 Similar to IL-10 Activates STAT1 and STAT3 and increases
— production of acute phase proteins such as
serum amyloid A, Alpha 1-antichymotrypsin,
and haptoglobin in hepatoma cell lines
