Page 156 - Clinical Hematology Atlas
P. 156
140 SECTION FOUR LEUKOCYTES
TOXIC GRANULATION
A B
FIGURE 14–5A Toxic granulation. FIGURE 14–5B Toxic granulation and Döhle body
(arrow). Cytoplasm may retain blue color due to
cell’s early release from bone marrow.
DESCRIPTION: Prominent dark purple-black
granules
LOCATION: Cytoplasm of neutrophils, unevenly
distributed
COMPOSITION: Primary granules
NUMBER: Few to many
Associated with: Wide range of conditions
including bacterial infection, sepsis and following
administration of granulocyte colony-stimulating
factor.
C
FIGURE 14–5C Normal segmented neutrophil for
comparison.
