Page 226 - Clinical Hematology Atlas

210 SECTION FIVE MISCELLANEOUS

HEMATOLOGIC MANIFESTATIONS OF SYSTEMIC DISORDERS

A B
FIGURE 22-1A Gaucher cell (BM 31000). FIGURE 22-1B Niemann-Pick disease (BM 31000).

DESCRIPTION: The Gaucher cell is a macrophage DESCRIPTION: The Niemann-Pick cell is a
20 to 80 mm in diameter, with one or more small, macrophage, 20 to 90 mm in diameter, with a
round to oval eccentric nuclei; cytoplasm has small eccentric nucleus and foamy cytoplasm. It
crumpled tissue paper appearance; found in bone is found in bone marrow and lymphoid tissue. The
marrow, spleen, liver, and other affected tissue. peripheral blood of patients with Niemann-Pick
disease may exhibit vacuolated lymphocytes.

C
FIGURE 22-1C Lymphocyte from Sanfilippo Syndrome (PB 31000).
DESCRIPTION: Peripheral blood lymphocytes containing azurophilic granules occasionally
surrounded by halos
Associated with: Mucopolysaccharide storage disorders