Page 283 - Review of Medical Microbiology and Immunology ( PDFDrive )

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272
PART III Basic Virology
Inhibited by entry inhibitors
(enfuvirtide, maraviroc)

CD4
Nucleus
CCR5
or CXCR4
Provirus
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Integration Transcription
RNA genomes
transcription
Precursor
mRNAs
Assembly into
by
nucleocapsid
Inhibited by
protease
DNA copy
reverse transcriptase
inhibitors (zidovudine
of genome
and others)
Inhibited
by protease
Inhibited by integrase
inhibitors
inhibitors (raltegravir)
(indinavir
and others)
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FIGURE 35–2
Replicative cycle of human immunodeficiency virus (HIV) showing the site of action of drugs used to treat HIV infection.
O
F
H
C
N
N
O
N
H N
H N
N
2
2
HO H C N HOCH 2 O N H F
2
O CH 2 HO H C O CH 2 HO
mebooksfree.com mebooksfree.com (acycloguanosine) HO NH •HCl C OH mebooksfree.com 3 mebooksfree.com mebooksfree.com
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CH
CH
2
HO
H C
2
2
Ganciclovir
Acyclovir
Trifluridine
O
O
P
O
O
CH
OH
C
H N
HN
N
2
Foscarnet
N
O
N
H
N
HOCH
2 O
HOCH
2 O
2
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N
OH
3
Ribavirin
Zidovudine
Amantadine
(azidothymidine)
FIGURE 35–3
Structures of some medically important antiviral drugs.
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