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UNIVERSITY RESEARCH COMMERCIALIZATION                      421



               • Faculty Service:                       DISCUSSION AND CONCLUSION
                 ◉ Outreach via electronic and personal means      Research universities must accommodate the need
                  significantly increased research faculty interac-   for translational benefits from the taxpayers’ research
                   tions on both the engineering and medical    funding. That doesn’t mean that scientific freedom is
                  campuses.                             to be sacrificed; on the contrary, good science is the
               • Process improvement:                   basis for commercialization. Furthermore, society
                ◉ By focusing on “fewer but better” inventions    needs to invest in commercialization. For example,
                  to add to the portfolio, we were able to free    in a December 2013 presentation at the TTS-Asia
                  up a greater portion of the patent budget to    Conference in Singapore, A*STAR (Singapore’s sci-
                  invest in new inventions as opposed to main-   ence and economic agency) chairman Lim Chuan
                  taining unlicensed inventions. Additionally,    Poh stated that 5% of every dollar spent on research
                  we ensured greater and deeper attention to    needs to be spent on commercialization. If we were
                  making the most promising ones successful.  to apply that rule to U.S. academic research funding,
                ◉  By applying Coulter-inspired, milestone-based    it would equate to $1.5 billion annually. In addition
                  Ignition awards, increased the number of com-   to universities’ investments in technology transfer,
                  mercializable projects (14).          the federal government has launched a number of
                ◉  By requiring matching funding for Launch    commercialization acceleration programs, such as
                  awards, increased the number that successfully    NIH National Centers for Accelerated Innovations
                  garnered follow-on commercial funding.  and Research Evaluation and Commercialization
               • BU new venture spin-offs since 2010 (>$150    Hub and NSF Innovation Corps. The Small Business
                million in cumulative VC equity funding):   Innovation Research and the Small Business Technol-
                ◉ Sample6 received $32 million in VC funding    ogy Transfer programs are similarly increasing the
                  (PIs: Jim Collins, Michael Koeris, Timothy    federal government’s focus on commercialization.
                  Wu):                                    There are still areas for improvement for a TTO
                  ■ Applying synthetic biology to pathogen    platform:
                   detection in food processing
                ◉ ByteLight raised $3 million and was acquired      • We developed but did not fully implement an IT
                  by Acuity (engineering students and PI: Tom       system to automate TTO workflow processes.
                  Little):                                 Existing TTO IT systems lean towards data man-
                  ■ Indoor position location using Light Emitting       agement rather than platform process man-
                   Diodes for both lighting and data commu-      agement.
                   nication                               • A key element in platform process management
                ◉  RayVio raised $40 million in VC funding (PIs:      is to develop a technology benchmark that we
                  Ted Moustakas, Yitao Liao):              call the Commercialization Readiness Level
                   ■ Developing ultraviolet light-emitting diodes      (CRL) (14). Figure 4 details such a process flow.
                   for disinfection and curing             Simply, the goal of a university TTO would be to
                ◉ Enbiotix raised $3 million (PI: Jim Collins):     manage every research project by improving its
                  ■  Developing novel anti-infective therapeutics     CRL score while making “collisions” with the
                ◉ Constant Therapy raised $2.8 million (PI:    market until the market (industry, entrepreneurs,
                  Swathi Kiran):                           or financiers) is ready to license the underlying
                  ■  Cognitive rehabilitation app for stroke, trau-     intellectual property.
                   matic brain injury, and other brain repair    • Develop an algorithm to match faculty research
                ◉  Synlogic raised $70 million in VC funding      with industry interest for related innovation
                  from Atlas Venture and New Enterprise Asso-   utilizing existing publicly accessible data sources.
                  ciates (PI: Jim Collins):                Use the results from this search to encourage
                  ■  Developing microbiome-related therapeutics     research faculty to engage with industry and to
                ◉  Allegro Diagnostics acquired by Veracyte for       submit invention disclosures.
                  $21 million (PIs: Avi Spira, Jerome Brody).    • An increasing portion of universities’ inventions
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