Page 14 - ALL drugs

Verapamil & diltiazem- Ca+2 channel blocekrs

Mech

Block Ca2+ channel result in: ↓ SA node automaticity

↓ AV conduction
↓ Myocardial contractility

Uses:

•
• supraventricular dysrhythmias only

Side effects:

•
• Bradycadia, AV-block, heart failure & peripheral edema

Drug interaction

• Inc.serum level of digoxin → ↑ risk of AV-block.

• Not used with β-blockers → bradycardia, AV-block