Page 11 - ALL drugs

• Highly lipid soluble accumulate in tissue (liver & lung

• Long t1/2 (25-110 days)
Mechanism :

1)
2) K+ channel→ delay repolarization →↑ ERP (resting state )

3)
4) Na+ channel, block Ca2+ channel & block β1 →↓automaticity, ↓

conduction, ↓ contractility
5) Coronary Dilator

• Called Universal Antiarrhythmic sur to those mechanism

• Uses:
Both
life threatening ventricular dysrhythmias, supraventricular arrhythmias

Adverse effects:

1)Pulmonary fibrosis & hepatic toxicity  as it accumulates in liver

2)Corneal microdeposits (photophobia, blurred vision or blindness

3)
4) Thyroid dysfunction

5)
6) Blue & gray discoloration of skin