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166 SEcTioN ii Microbiology ` microbiology—Virology Microbiology ` microbiology—Virology

HSV identification Viral culture for skin/genitalia.
CSF PCR for herpes encephalitis.
A
Tzanck test—a smear of an opened skin vesicle to detect multinucleated giant cells A commonly
seen in HSV-1, HSV-2, and VZV infection. PCR of skin lesions is test of choice.
Tzanck heavens I do not have herpes.
Intranuclear eosinophilic Cowdry A inclusions also seen with HSV-1, HSV-2, VZV.

Receptors used by VirUs recePtors
viruses CMV Integrins (heparan sulfate)
EBV CD21
HIV CD4, CXCR4, CCR5
Parvovirus B19 P antigen on RBCs
Rabies Nicotinic AChR
Rhinovirus ICAM-1 (I came to see the rhino)

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