Page 450 - First Aid for the USMLE Step 1 2020, Thirtieth edition [MedicalBooksVN.com]_Neat

406 SectIon III Hematology and oncology ` hematology and oncology—anatomy Hematology and oncology ` hematology and oncology—anatomy

` hematology and oncology—anatomy

Hematopoiesis

Multipotent stem cell

Myeloid stem cell Lymphoid stem cell

Erythropoiesis Thrombopoiesis Granulocytopoiesis Monocytopoiesis Lymphopoiesis
Erythroblast Megakaryoblast Myeloblast Monoblast Lymphoblast
Bone marrow

Reticulocyte
Megakaryocyte Band

Blood

Erythrocyte Platelets Eosinophil Basophil Neutrophil Monocyte B cell T cell NK cell

Tissues

Macrophage Plasma cell T-helper T-cytotoxic
cell cell

Neutrophils Acute inflammatory response cells. Numbers Hypersegmented neutrophils (nucleus has 6+
 in bacterial infections. Phagocytic. lobes) are seen in vitamin B / folate deficiency.
A 12
Multilobed nucleus A . Specific granules A left shift with  band cells (immature
contain leukocyte alkaline phosphatase neutrophils) reflects states of  myeloid
(LAP), collagenase, lysozyme, and proliferation (eg, bacterial infections, CML).
lactoferrin. Azurophilic granules (lysosomes) Important neutrophil chemotactic agents: C5a,
contain proteinases, acid phosphatase, IL-8, LTB , kallikrein, platelet-activating factor.
4
myeloperoxidase, and β-glucuronidase.

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