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RepRoductive  ` REPRODUCTIVE—EmbRyOlOgy             RepRoductive  ` REPRODUCTIVE—EmbRyOlOgy           SectioN iii      619




                  Aortic arch derivatives  Develop into arterial system.
                   1st                   Part of maxillary artery (branch of external   1st arch is maximal
                                          carotid)

                   2nd                   Stapedial artery and hyoid artery        Second = Stapedial
                   3rd                   Common Carotid artery and proximal part of   C is 3rd letter of alphabet
                                          internal Carotid artery
                   4th                   On left, aortic arch; on right, proximal part of   4th arch (4 limbs) = systemic
                                          right subclavian artery
                   6th                   Proximal part of pulmonary arteries and (on left   6th arch = pulmonary and the pulmonary-to-
                                          only) ductus arteriosus                  systemic shunt (ductus arteriosus)


                                                                      3rd            3rd

                                                                      4th

                                                       Right recurrent               4th  Left recurrent laryngeal nerve
                                                       laryngeal nerve                   loops around aortic arch distal
                                                       loops around right                to ductus arteriosus
                                                       subclavian artery             6th
                                                                      6th
                                                             Truncus arteriosus
                                                                                     Descending aorta

                                                                        6 months postnatal



                  Pharyngeal apparatus   Composed of pharyngeal clefts, arches,   CAP covers outside to inside:
                                          pouches.                                  Clefts = ectoderm
                                         Pharyngeal clefts—derived from ectoderm. Also   Arches = mesoderm + neural crest
                                          called pharyngeal grooves.                Pouches = endoderm
                                         Pharyngeal arches—derived from mesoderm
                                          (muscles, arteries) and neural crest (bones,                       Pharyngeal floor
                                          cartilage).                                                               Cartilage
                                         Pharyngeal pouches—derived from endoderm.                        I         Nerve
                                                                                                                    Artery
                                                                                                         II
                                                                                                        III
                                                                                                       IV
                                                                                      Cleft
                                                                                      Arch            VI
                                                                                      Pouch



                  Pharyngeal cleft       1st cleft develops into external auditory meatus.
                  derivatives            2nd through 4th clefts form temporary cervical sinuses, which are obliterated by proliferation of 2nd
                                          arch mesenchyme.
                                         Persistent cervical sinus Ž pharyngeal cleft cyst within lateral neck, anterior to sternocleidomastoid
                                          muscle (does not move with swallowing, vs thyroglossal duct cyst).














          FAS1_2019_15-Repro.indd   619                                                                                 11/7/19   5:52 PM
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