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C.  Specific immunity: B-cell activation
                 B lymphocytes

                          Antigen binding
                                      B cell
                                                         Activation
                                     IgD, IgM
                                     monomer
           “Naive”                Antibody
                                  network
            B cell
                                                                       Immune System III
                                                         Internalization

                           1


                                                                       Plate 4.6
          T H2  cell                                      Processing
          (see plate B3)
                                                    HLAII
                       Cooperation of
                       T H2  cell and B cell
             T H2  cell                  B cell
                                  TD  HLAII
                    CD4          antigen
              T-cell receptor
                                           Presentation
               CD40 ligand      CD40
                         IL-4
               2
                         IL-5
                         IL-6

                                     Proliferation


                                                      Plasma cell
                           3
                                   Differentiation

                                                       According to
                                                       class switching
                                                        Immun-
                                IgM         IgG  IgA  IgE  globulins
                                 Specific humoral immune response     99
                                        (see plate A)

       Despopoulos, Color Atlas of Physiology © 2003 Thieme
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