Page 256 - Color_Atlas_of_Physiology_5th_Ed._-_A._Despopoulos_2003

A. HCl secretion by parietal cells
Anion exchanger
–
3 Cl channel
Cl – Cl –
– 2 –
HCO 3 HCO 3
CA
Lumen of gland OH – + CO 2 CO 2
Blood side
+
+
H /K ATPase H 2 O
Na /H exchanger
+
+
H + H +
ATP
1 Na +
+
K channel ATP Gastric Juice
K + K +
+
+
Na /K ATPase
Parietal cell
Plate 10.9
B. Regulation of gastric acid secretion
2 Fundus Vagus nerve
Vagus nerve
CGRP
ACh D cell
M 3
Food Mechanical SIH
stimulus
H 2 H cell
Parietal cell
1 HCl Histamine
CCK B
HCl Lumen Gastrin
Systemic
Chemical circulation
stimulus Pepsin
3 Antrum Vagus nerve
pH < 3 Amino
acids, ACh
etc. pH < 3
Gastrin
D cell CGRP
SIH
Secretin,
GIP
G cell GRP

Gastrin 243

Despopoulos, Color Atlas of Physiology © 2003 Thieme
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