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52      PART 1: An Overview of the Approach to and Organization of Critical Care

                     ■  COMPUTERIZED PHYSICIAN ORDER ENTRY                • Closed-loop control: Based on expert systems, this type of CDDS

                 Computerized physician order entry (CPOE) can be used to order   includes a computer linked directly to a technical device, with
                                                                         the capability to adjust that device without human intervention.
                 medications, laboratory tests, radiologic investigations, and consultation
                 services. In many instances, CPOE has been demonstrated to decrease   Mechanical ventilators and automated target control drug deliv-
                                                                         ery are examples of closed-loop control devices that are equipped
                 the time taken to complete an order, decrease associated complications
                 (handwriting identification and medication errors), and improve  billing   with the capability to automatically adjust one parameter based on
                                                                         another.
                 management. One of the major  reported effects of CPOE is a 55%
                 medication errors is almost twice that found in other hospital settings.    ■  BEDSIDE MONITORING
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                 decrease in serious medication errors.  In the ICU, the rate of preventable
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                 Earlier study in 1993 found that CPOE implementation lowered costs per   Bedside monitors are an essential part of the ICU electronic environment
                 admission by $887 and length of stay decreased by 0.89 days.  Advanced   and generate a large quantity of data. Bedside monitoring is a specific
                                                            16
                 CPOE systems can also utilize elements of CDSS.       part of device technology that is a subset of biomedical technology.
                   More widespread use of CPOE has, however, uncovered some new errors   The development of bedside monitors correlates with advances in
                 and underlines the importance of post adoption safety surveillance and   hardware and software technology. Gradual incorporation of microcom-
                 adverse event reporting, a provision that is currently being debated as part   puters and sophisticated algorithms has increased the ability of monitors
                 of the ongoing discussion about meaningful use. The problem with CPOE   to calculate and display meaningful clinical parameters. Modern moni-
                 deployments can be overcome by systematically developing and applying   tors can communicate with EHR and archive data. The rate of change
                 human-centered design, implementation, and evaluation methods led by   of patient monitors is now limited by the rate of advance in sensor
                 practitioners experienced in medical informatics.  In addition to concerns   technology. The future generation of medical sensors should be wire-
                                                   17
                 about increased complexity and the potential negative impact on patient-  less, portable, durable, noninvasive, and especially for military medicine
                 centered outcomes, implementation of CPOE can be slow, resource inten-  cheap and disposable.
                 sive, and costly. Indeed the cost of implementation has emerged as a critical   The rationale for current use of physiological monitoring in the ICU
                 barrier to providers working in smaller group practices.  is to facilitate the detection (and prediction) of physiological instabil-
                     ■  CLINICAL DECISION SUPPORT SYSTEM               ity. Reliance on physiologic data alone to trigger alerts about complex
                                                                       disease states such as sepsis has led to poor specificity. Monitoring
                 The  US  Office  of  the  National  Coordinator  for  Health  Information   data needs to be integrated with other patient-related information.
                 Technology (ONC) defines Clinical Decision Support System (CDSS)   For example, arterial blood pressure should be evaluated together with
                 as providing “clinicians, staff, patients, or other individuals with knowl-  information about vasoactive drugs administration. Modern ICUs have
                 edge and person-specific information, intelligently filtered or presented   multiple monitoring devices that display and archive data through
                 at appropriate times, to enhance health and health care. CDSS encom-  charting programs linked to the EHR. This capability facilitates the
                 passes a variety of tools to enhance decision making in the clinical   development of algorithms that combine information contained within
                 workflow.  These  tools  include  computerized  alerts  and reminders  to   the EHR (ventilator settings, laboratory values, or imaging reports) with
                 care providers and patients, clinical guidelines, condition-specific order     vital signs data (heart rate, respiratory rate, temperature, pulse oximetry)
                 sets, focused patient data reports and summaries, documentation   from a bedside monitor and form the basis of smart alerts. 21
                   templates, diagnostic support, and contextually relevant reference infor-    ■
                 mation, among other tools.”                              TELEMEDICINE
                   Computer technologies should facilitate and enhance the clinician’s   The ICU manpower shortage and lack of on-site expertise has created
                 ability to make decisions for the benefit of the patient. A classical   a demand for remote consultations and monitoring. Surprisingly, back
                 example of a successful CDSS is the Health Evaluation Through Logical   in 1997, only 27% of ICU patients were treated by intensivists.  One of
                                                                                                                    22
                 Processing (HELP) system. 18                          the emerging technologies that may help deal with this problem is tele-
                   CDSS can support clinical decision making in a number of ways.  medicine (Fig. 8-3). The American Telemedicine Association defines
                                                                       telemedicine as “the use of medical information, exchanged from one
                    • Alert: Notification about an event or inaction. Examples include
                   drug-drug interactions, allergy, dosing errors, or blood transfusion   site to another via electronic communications, to improve patients’
                   ordering.  There are two modes of interaction: passive guidance   health status”. The first reported use of telemedicine (intermittent con-
                          19
                                                                                                     23
                   when notification is delivered in a way that does not interrupt work-  sultative advice) was published in 1982.  Until recently, technological
                   flow, and active alerting, which forces clinicians to take action and   issues represented the major barrier to widespread implementation of
                   potentially interrupt workflow.                     telemanagement in the ICU. While these technological barriers have
                                                                       been overcome and several companies offer commercial packages for
                    • Critique the decision and propose alternatives:  Computer   ICU telemedicine, the evidence supporting their ability to add value to
                   system analyze the decision and suggest alternative solutions if   the care of ICU patients is conflicting. In addition, the start-up costs,
                   needed. Guidance for blood transfusion is an example of such a   estimated at up to $50,000 per ICU bed, and ongoing staffing expenses
                   system. 20                                          have emerged as the key barriers to more widespread adoption.
                    • Expert systems: Developed in medicine for over 40 years. In general,
                   expert systems can be classified into two categories: diagnostic or     ■  MOBILE COMPUTING
                   therapeutic. Most use Bayesian probability to generate a recommen-  The development of mobile networks and hardware opens up exciting
                   dation but systems have been developed which utilize fuzzy logic,
                   neural networks, pattern matching, and machine learning.  possibilities for the future of the EMR. Wi-Fi networks and high-speed
                                                                       cellular networks (3G and 4G) allow access to data from remote loca-
                    • Retrospective quality assurance: This is a post hoc analysis of prior   tions. The most recent generation of handheld devices offer very high
                   decisions and suggestions for better future solutions.  screen resolution comparable with desktop monitors, intuitive gesture-
                    • Reference links to online guidelines and training materials   based interactions, and integration with desktop applications. Tablet
                   (Infobuttons): During the examination of the patient’s EMR, a clini-  computers are becoming lightweight (~2 lb) with unprecedented battery
                   cian has access to content dependent references for data interpreta-  life (~10 hours) and no boot time compared to laptops. These features
                   tion and potential therapeutic options. Examples of such Infobutons   have  made  them  popular  with  health  care  providers.  According  to
                   includes: UpToDate, Isabel, Epocrates, Micromedex, and InfoButton   Manhattan Research, “Physicians in 2012: The Outlook for on Demand,
                   Access from Thomson Reuters.                        Mobile, and Social Digital Media,” the number of physicians who own







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