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                  194    PA R T  I I / Physiologic and Pathologic Responses
                  internal clock and the external schedule. Delayed sleep phase dis-  conducted for sleep disorders in infants and children. Studies in
                  order, when sleep time is delayed in relation to the desired clock  adult populations are limited and focus on patients with comor-
                  time, and advanced sleep phase disorder, when the patient goes to  bid medical conditions. One study examined aromatherapy mas-
                  sleep in the early evening and wakes up earlier than desired in the  sage for hospice patients using self-report measures of sleep. Al-
                  morning are two common circadian sleep-related  distur-  though this study reported no benefits in quality of life or pain
                  bances. 285,286  Patients with a delayed sleep phase have been re-  control, there were statistically significant improvements in self-
                  ported to benefit from early morning light exposure. This requires  reports of sleep and depression. 295  Another randomized study
                  bright light exposure to be given in the morning as close to the pa-  compared therapeutic massage and relaxation tapes in the man-
                  tient’s scheduled arising time as possible. Light therapy delays the  agement of stress with both modalities showing improvements in
                  shift toward a later phase and may be useful in sustaining a  sleep, but no significant benefit of one over the other. 296  Among
                  24-hour circadian period. Evening bright light exposure is useful  patients with cardiovascular disease, massage therapy and its ef-
                  for treating advance sleep phase disorders by impeding the circa-  fects on sleep have received little attention.
                  dian sleep phase. 287                                 Another form of manipulative therapy is acupressure, a nonin-
                     Natural sunlight or artificial light, using a light box, can be  vasive technique that involves stimulation of meridian or acu-
                  used to administer light therapy. Artificial light requires using  points on the body using finger pressing movements. It can be ad-
                  10,000 lux for 30 to 40 minutes upon awakening. Evening light  ministered by nursing staff or by family members of a patient.
                  exposure is decreased to attain positive results in those with de-  Acupressure in end-stage renal patients has shown improvements
                  layed phase sleep disorders. Blue-blocking sunglasses may be worn  in self-reported sleep quality, sleep latency, and sleep efficiency. 297
                  to counter the phase-delaying effect of evening light exposure. Re-  Acupressure has had limited use in cardiac patients for sleep, re-
                  sponse is usually seen in 2 to 3 weeks and often requires indefinite  quires further study, and has exhibited little effectiveness for low-
                  treatment. Advanced phase disorder patients require a light box in  ering nausea and vomiting following cardiac surgery. 298
                  the evenings. The use of sun glasses that block blue light in the
                  morning may also be beneficial. 41,286,288,289         Meditation. While there are several forms of meditation, one
                                                                      of the most commonly studied for insomnia is mindfulness med-
                  Complementary and Alternative Therapies             itation. Stress reduction may be one of the mechanisms by which
                  One of the most frequent uses of complementary and alternative  meditation can exert a beneficial effect on sleep and most of the
                  medicines (CAM) is in the treatment of sleep disturbances. While  studies that have demonstrated improved sleep during meditation
                  the terms are often used synonymously, a more accurate statement  therapy have been conducted as stress reduction studies. In this re-
                  is the National Institutes of Health—National Center for Com-  gard, it can be used as part of a cognitive therapy approach. In ad-
                  plementary and Alternative Medicine (NCCAM) definition that  dition to stress reduction, there may also be differences in slow-
                  complementary medicines are “used together with conventional  wave sleep as a result of meditation. Few studies  have used
                  medicine,” while alternative medicines are “used in place of con-  meditation as a method to improve sleep in patients with cardio-
                  ventional medicine.” The NCCAM lists five broad categories of  vascular disease but recent data from a yoga intervention, which
                  CAM therapies including: (1) alternative medical systems. These  included posture, breathing, and meditation, suggests it may im-
                                                                                          299
                  include acupuncture, Ayurveda, or homeopathy; (2) biologically  prove autonomic function.
                  based practices, such as herbal products; (3) mind-body medicine,  Yoga. Yoga incorporates the holistic components of physical
                  meditation, Tai Chi, yoga, and biofeedback; (4) manipulative and  activity, specific postures, breathing exercises, and a philosophic
                  body-based practices, massage-based therapies; and (5) energy  attitude toward life. It has been shown to reduce anxiety levels and
                  medicine that focuses on the use of energy fields, including bio-  physiological arousal in cardiac patients. 300  A randomized, paral-
                  electromagnetic-based therapies.
                                                                      lel group study conducted over a 6-month treatment period com-
                     Melatonin. Melatonin is a hormone produced by the pineal  pared yoga (60-minute session 6 days a week, with a 15-minute
                  gland that is thought to play an important role in regulating the  evening session), Ayurvedic therapy, and wait-list control in 69
                  sleep–wake cycle. During the daytime, circulating levels are low  older adults. Self-reported sleep measures were assessed and
                  with nocturnal levels becoming elevated, which coincide with the  demonstrated a 1-hour increase in total sleep time relative to pre-
                  sleep phase. Melatonin can alter the timing of the circadian  treatment in the yoga group that was significantly higher than
                  sleep–wake cycle. 290  Melatonin also has sedative effects, possibly  changes in the wait-list or Ayurveda groups. 301
                  by inhibiting the suprachiasmatic nucleus. Melatonin has exhib-
                  ited positive effects on the cardiovascular system. 291,292  Studies of  Tai Chi. Tai chi is a low- to moderate-intensity traditional
                                                                      Chinese exercise that includes a meditational component. Previ-
                  the effectiveness of melatonin have been inconsistent using both
                                                                      ous findings supports that Tai chi enhances aerobic capacity,
                  wrist-worn actigraphy and PSG to document sleep parameters.
                                                                      muscular strength, endothelial  function and psychological
                  Melatonin is well tolerated by most individuals in the dose range  302
                  of 0.1 to 10 mg with few reported adverse events. 293  However,  wellbeing.  A study of the effects of tai chi (three 60-minute ses-
                                                                      sions for 24 weeks) in older adults, in comparison to low-impact
                  melatonin may reduce the antihypertensive effectiveness of cal-
                                                                      exercise, noted that Tai chi improved self-reported sleep duration
                  cium channel blockers to a mild degree. Patients taking nifedip-  303
                                                                      by 48 minutes.  General health-related quality of life and day-
                  ine, who were treated with melatonin, showed a mean increase in
                                                                      time sleepiness levels also improved. Tai chi appears to be safe and
                  systolic blood pressure of 6.5 mm Hg, and in diastolic blood pres-
                  sure of 4.9 mm Hg. 294                              effective for patients with MI and HF, and post-CABG surgery.
                                                                             304
                                                                      Yeh et al  reported improved sleep time in patients receiving
                     Manipulative and Body-Based Practices. The manipula-  12 weeks of Tai chi training compared to controls. Therefore, Tai
                  tive and body-based practices include a wide range of hands-on  chi may be viewed as an alternative exercise program that may
                  interventions. Massage therapy studies have primarily been  enhance sleep for selected patients with cardiovascular diseases.
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