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                                                                                             C HAPTER  8 / Sleep   197
                   22 hours), estazolam (10 to 24 hours), quazepam (25 to 100 hours),  physiological changes during sleep that adversely affect their
                   and flurazepam (74 to 160 hour for active metabolite). 317  health status. Sleep disorders contribute to risk for cardiac disease
                                                                       and to other cardiac risk factors. Although beliefs regarding the re-
                   Nonbenzodiazepines                                  lationship between sleep and well being are widely shared, hospi-
                   The nonbenzodiazepines, recently approved by the FDA for in-  tal practices are rarely designed to encourage optimal sleep. Re-
                   somnia, possess chemical structures that differ from each other as  search is needed to clarify the role of night-time sleep and daytime
                   well as the traditional benzodiazepines. 315,317  These medications  naps in recovery from cardiovascular disease and surgery (e.g.,
                   bind to the GABA receptor at a selective and limited recognition  what are optimal sleep patterns?) and to identify nursing inter-
                   site, explaining the absence of myorelaxant and anticonvulsant ef-  ventions that prevent sleep deprivation, minimize adverse sleep-
                   fects. Three nonbenzodiazepine drugs (and their half-lives) are in-  related physiological changes, and promote good sleep.
                   dicated for insomnia—zolpidem (regular formulation 2.5 hour;
                   continued release 2.8 hours), zaleplon (1 hour), and eszopiclone
                   (6 hours in adult; 9 hours in elderly) (see Table 8-1). These med-  R EFERENCES
                   ications  have  demonstrated efficacy in acute management of  1. Javaheri, S. (2005). Sleep and cardiovascular disease: Present and future.
                   chronic insomnia. Longer term studies also suggest their efficacy.  In M. H. Kryger, T. Roth, & W. C. Dement (Eds.), Principles and prac-
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                   ing, and sleep eating. 315,318  This class of medications does not ap-  2. Somers, V. K., White, D. P., Amin, R., et al. (2008). Sleep apnea and car-
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