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                  716    PA R T  I V / Pathophysiology and Management of Heart Disease
                  Physical Assessment                                 TEE provides a more detailed look at the mitral valve and chordal
                                                                      structures. 12
                  The classic auscultatory finding of MVP is a midsystolic click  Cardiac catheterization can be used to rule out CHD as the
                  with mid- to late systolic murmur (see Table 29-3). The murmur  origin of chest pain. Left ventriculography can demonstrate ab-
                  occurs secondary to regurgitant flow when the mitral valve leaflets  normal motion of the mitral valve and help determine the degree
                  fail to approximate. Patients with MVP may have the murmur or  of regurgitation.
                  click or both. Findings may also vary over time. When the degree  Electrocardiography is nondiagnostic. The electrocardiogram
                  of mitral regurgitation is mild-to-moderate or less, heart rate and  may be normal or have nonspecific ST-T-wave changes in the in-
                  blood pressure may be normal. Additional physical findings may  ferior leads (II, III, and aVF) and occasionally in the anterolateral
                  include thin body habitus, pectus excavatum, straight back syn-  leads (V 4 through V 6 ). The ST-T-wave changes may become more
                                                                           V
                  drome, and scoliosis.                               notable with exercise. Premature atrial and ventricular complexes
                                                                      may also be identified. Exercise testing may be used to help rule out
                  Diagnostic Tests                                    the cause of the chest pain.
                                                                        Chest radiography is often normal and is usually nondiagnostic
                  Echocardiography plays a key role in the diagnosis of MVP. Ab-  for MVP. Patients with acute mitral regurgitation secondary to
                  normal systolic motion of one or both of the mitral valve leaflets  chordal rupture have pulmonary congestion but not cardiomegaly.
                  superior to the annular plane can be seen (Fig. 29-7). Doppler  Patients with chronic severe mitral regurgitation have an enlarged
                  echocardiography gives additional evidence of valve regurgitation.  cardiac silhouette secondary to left atrial and left ventricular en-
                                                                      largement in addition to pulmonary congestion (Fig. 29-8).
                                                                      Medical Management
                                                                      Asymptomatic patients with MVP require no therapy.  -Blockers
                                                                      or calcium channel blockers may be used to help alleviate palpita-
                                                                      tions or chest pain syndrome.
                                                                      Surgical Management
                                                                      Patients with MVP and severe mitral regurgitation or flail leaflets
                                                                      should be evaluated for surgery. They often can undergo repair
                   A
                                        LV
                                                   PL
                                     AP
                   B
                                                                      ■ Figure 29-8 Chest radiograph of 51-year-old male patient with
                  ■ Figure 29-7 (A) Long-axis echocardiographic view of mitral  history of MVP and repair (note annuloplasty ring marked with ar-
                  valve with bileaflet prolapse above the annular plane into the left  row). Patient’s valve repair has failed and his mitral regurgitation is
                  atrium. (B) Illustration corresponding to echocardiogram. RV, right  now severe. Patient is now in severe heart failure with notable bilat-
                  ventricle; LV, left ventricle; AP, annular plane; PL, prolapsing leaflet.  eral pleural effusions and cardiomegaly.
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