Page 117 - Color Atlas Of Pathophysiology (S Silbernagl Et Al, Thieme 2000)

A. Interstitial Nephritis
2
Descending
pathogens Deposition of concrements:
calcium salts, uric acid
Toxic damage,
e.g. phenacetin
Allergic reaction,
e.g. penicillin
Rejection reaction
after transplantation
Interstitial nephritis
Inhibitors of
1 prostaglandin synthesis
Immune defense Interstitial Nephritis
Ischemia
Lesions of
distal nephron
Plate 5.8
3

Ascending pathogens
Ca 2+
Outflow obstruction
Na +
K +
4 O In
urine
H 2 N C NH 2 H +
Osmotic
pressure in
CO 2
renal medulla
–
NH 3 H 2 PO 4
+
+ H + H secretion
NH 4
Systemic
2–
HPO 4 acidosis Alkaline urine
+
Mg 2+ Ca 2+ Na reabsorption
Impaired urinary
concentration Natriuresis
+
K secretion
Precipitation of Hyperkalemia
phosphate salts 107
Silbernagl/Lang, Color Atlas of Pathophysiology © 2000 Thieme
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