Page 171 - Color Atlas Of Pathophysiology (S Silbernagl Et Al, Thieme 2000)

A. Causes and Consequences of Chronic Pancreatitis

Tumor, stricture, papillary stenosis

Pancreas
Alcohol abuse
Occlusion of
Pancreatitis
main pancreas duct

Pancreatic juice:
Secretion of Citrate concentration
–
HCO 3 and fluid Lithostatin concentration Chronic
Plate 6.14
Proenzyme concentration Calcium salt
precipitation

Normal ERP

Protein
plug

Duct
distension
Calcium
deposition

Epithelial lesions

Enzyme activation

Chronic inflammation and fibrosis of exocrine
and endocrine pancreas, damage to neighboring organs
Tissue atrophy Pain Diabetes mellitus Obstructive
Ductal stenosis Malabsorption Pancreatic ascites jaundice
Diarrhea
Thrombosis of portal
Periductal fibrosis Weight loss and splenic veins Pseudocysts 161
Photo of dilated duct from: Thurn P. et al. Einführung in die radiologische Diagnostik. 10th ed. Stuttgart: Thieme; 1998
Silbernagl/Lang, Color Atlas of Pathophysiology © 2000 Thieme
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