Page 183 - Color Atlas Of Pathophysiology (S Silbernagl Et Al, Thieme 2000)

A. Fibrosis and Cirrhosis of the Liver

Noxious factors (alcohol,
viral hepatitis, etc.)
Liver
Necrosis
Hepatocyte the
Enzyme leak
Cell debris Cirrhosis of
Matrix

Liver lobule
Cytokines and other Fibrosis and
matrix components
Chemotaxis of
inflammatory cells
Activation of
Kupffer cells Plate 6.20
Kupffer cell
Granulocytes
Lymphocytes

Growth factors
and Monocyte
cytokines
MCP-1 Chemotaxis

Ito (fat) cell Chemotaxis

TGFβ
Myofibroblast Macrophage

Extracellular
matrix production Fibroblast
proliferation
Collagen type I, III, IV
Proteoglycans
Matrix glycoproteins Cholestasis

Fibrosis Cirrhosis Portal
hypertension
Nodular regeneration
with loss of lobular structure Metabolic
failure 173

Silbernagl/Lang, Color Atlas of Pathophysiology © 2000 Thieme
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