Page 223 - Color Atlas Of Pathophysiology (S Silbernagl Et Al, Thieme 2000)
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+
        C.  Na  Uptake and Blood Pressure  D.  Mortality and Hypertension
        kPa  mmHg
            200
                        d               50
                      Primary hypertension    Mortality rate
        20  150    c  or abnormal       Died (%)  40  (in men,
                                              follow-up of 20 years)
                      renal function
                e            Normal     30
            100    a    b
         10                             20
                   Normal  uptake  High  uptake
             50                          10

         0    0                        Age  50    55   60   65
                 1x  2x  3x  4x  5x                                    Hypertension III
                            +
              Uptake (= excretion) of Na and water  Blood pressure levels in 45th year of life
                  (multiples of ‘normal’)    132/85  152/95  mmHg
                                             132/90  162/100
                                                 (after Society of Actuaries:
                           (after Guyton et al.)  Build and Blood Pressure Study, 1959)
        E.  Consequences of Hypertension                               Plate 7.20
                                Arterial hypertension
         TPR
             +
            Na  excretion
                                                       Hypertensive
                                                       encephalopathy





            Left ventricular
            hypertrophie,                                  Bleeding
            heart failure
                                      (Photo: U.Pfeifer)
           Renal
           ischemia


          Renal failure                                  Malacia


                   Myocardial
                   infarction
                               Peripheral
                               vascular disease
                                                   Apoplexy           213
                                                           (after Lohmann)
       Silbernagl/Lang, Color Atlas of Pathophysiology © 2000 Thieme
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