Page 25 - Color Atlas Of Pathophysiology (S Silbernagl Et Al, Thieme 2000)

A. Mechanisms of Tumor Genesis
Thyroid hormones: Growth Growth-promoting
factors
T 3 , T 4 hormones
Sis
Receptors
ErbB
1 P Small G-protein
Abl, Fes Ras
Cell membrane Src GRB 2 SOS
P
P GTP of Tumor Cells
Tyrosine kinase Serine/threonine kinase
ErbA Raf
Nuclear 2
receptor GDP
3
MAPK cascade Development
Chemical
cancerogens Transcription factors:
E2F, DP1, Fos, Jun, Myc, Myb, Rel
Radiation
Inflammation, Plate 1.7
lesions
(many mitoses)
Inheritance Mutations Oncogenes
Viruses
6
DNA repair
Cell nucleus
p53
p53
p21
DP1 DP1
D-CDK 4
Rb Rb 5
E-CDK 2
4 E2F E2F
Uncontrolled
=Oncoproteins Controlled cell division tumor cell division
B. Malfunction of Ras C. Development of Tumor Cells
Ras Ras Viruses
active mutated Mutations Promoters
GTP GTP 1
Bcl2 3
GAP M 2
Mutated cells
Ras Ras
inactive active Tumor cells
P GDP GTP
Normal cell
controlled Cell division uncontrolled Apoptosis 15

Silbernagl/Lang, Color Atlas of Pathophysiology © 2000 Thieme
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