Page 29 - Color Atlas Of Pathophysiology (S Silbernagl Et Al, Thieme 2000)

A. Life Expectancy
10 6
100 5
10
1970 (USA)
80 10 4 3
% of survivors 60 50000 15000 3000 Survivors 10 2
10
years ago
vears ago
(Europe)
40
(Europe)
10
20
years ago
(Africa) 1 98 100 102 104 106 108 110 Expectancy
0 20 40 60 80 100 Age (years)
1 Age (years) 2 Life expectancy of 98-year-old persons
B. Dividing Capacity of Cultured Cells C. Age-dependent Bodily Functions
Nerve conduction
20 Pulmonary 100 Cardiac velocity Aging and Life
Number of cells (x10 5 ) 15 Progeria 100-year-old of: Function (%) 80 Max. breathing metabolic Plate 1.9
fibroblasts
output
Basal
Newborns
rate
10
60
persons
capacity
syndrome)
0 5 (Werner’s 40
0 20 40 60 80 20 40 60 80 100
Division generations Age (years)
D. Endocrinology of Aging
Biological clock (?)
Anterior
pituitary
‘Somatopause’: ‘Adrenopause’:
Skin STH ACTH ( ) Muscle weakness
thickness ? Obesity
Muscle mass Heart disease
Bone mass IGF-1 LH/FSH DHEA(S) Type II
diabetes mellitus
Fat mass Immune
response
Meno-
400
Urinary estrogens (µg/d) 200 Puberty pause Free testosterone (index) 160 Puberty pause’
‘Andro-
120
80
0 40 Partly after Lamberts et al.
0 ..12 13 ...... 40 50 60
Age (years) 0 0 10 20 30 40 50 60 70 80
Age (years)
Increased risk of:
– coronary atherosclerosis – muscle weakness
– osteoporosis – anemia
– Alzheimer’s disease – mood swings 19
Silbernagl/Lang, Color Atlas of Pathophysiology © 2000 Thieme
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