Page 31 - Color Atlas Of Pathophysiology (S Silbernagl Et Al, Thieme 2000)

A. Fever
1 Exogenous pyrogens
(lipopolysaccharides)
Bacteria,
viruses

Macrophages
Preoptic area,
OVLT Kupffer cells
Noradrenergic Endogenous pyrogens of the liver
(= div. cytokines)
tracts
2 Via blood
Nucl. solitarius Vagal nerve
Replication of
pathogens
Virus replication
A2 Fever
A1
3 Plate 2.1
Norepinephrine

Medulla Arachidonic acid Antipyretics
oblongata (e.g. acetyl-
salicylic acid)
4
PGE 2 PGE 2
Endogenous antipyretics
(ADH, α-MSH, CRH)
39 5 Fever
Core temperature °C 38 Set level Actual level

37 (after C. Jessen)
0 1 2 3 4 5
Feeling cold, Feeling hot, hours
little cutaneous high cutaneous
blood flow, blood flow,
rigor sweating
Energy
metabolism Fever delirium Febrile fits
(infants, young children)
Heart rate Slow-wave Headache,
–1
(8 –12 min /°C) sleep joint pain 21
Silbernagl/Lang, Color Atlas of Pathophysiology © 2000 Thieme
All rights reserved. Usage subject to terms and conditions of license.