Page 297 - Color Atlas Of Pathophysiology (S Silbernagl Et Al, Thieme 2000)

A. Diabetes Mellitus: Type I
Viral infection Autoimmune disease
?
Genetic
? disposition ?
?
Destruction of beta cells
TYPE l
10%
of all Beta cells
(pancreas)
diabetics
Absolute Mellitus: Causes
insulin deficiency

Lipolysis Hyperglycemia Protein
breakdown Diabetes
B. Diabetes Mellitus: Type II
Plate 9.16
Familial Substrate uptake
disposition Substrate consumption

Lipolysis Fatty acids
Obesity
TYPE lI Ketone bodies
90% Insulin Target cell
of all
diabetics Insulin insensitivity
Relative
insulin deficiency

Hyperglycemia
C. Other Causes of Diabetes Mellitus

Unresponsive
Abnormal receptor Postreceptor
insulin release defect
Removal of
pancreas Severe
Pancreatic Insulin infections
disease Target cell
Antibodies
Antagonistic
hormones
Hyperglycemia (e.g. in pregnancy) 287

Silbernagl/Lang, Color Atlas of Pathophysiology © 2000 Thieme
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