Page 301 - Color Atlas Of Pathophysiology (S Silbernagl Et Al, Thieme 2000)

A. Late Complications of Diabetes Mellitus
Persistent
glucose excess Hyper-
(hyperglycemia) osmolarity
4 Fibrinogen
6
Sorbitol Haptoglobin Complications
Glycosylation of proteins: Clotting
factors V and Vlll
BPG AGE

HbA 1c
Blood clotting
Thickening of Mellitus: Late
basal membrane Blood
11 viscosity
O 2 release
Amino acids
5 Diabetes
?
Microangiopathy Prone to 12
Osmotic infection Big
1 swelling 7 babies
Hyper- Plate 9.18
Pyelo- filtration
Lens of eye Endothelial nephritis
cells
Schwann
cells Renal failure Glomerulo- 9
2 sclerosis
Cataract
Proteinuria
Impaired nerve
conduction
Hypertension
Cellular loss
of myoinositol Retinopathy
8
VLDL
? Blindness
10
Macroangiopathy

Polyneuropathy
Autonomic Peripheral
nervous 3 Myocardial
regulation infarction vascular disease,
Reflexes placental perfusion
Sensory (in pregnancy)
responses Stroke
291
Photo: Hollwich F. Taschenatlas der Augenheilkunde. 3rd ed. Stuttgart: Thieme; 1987
Silbernagl/Lang, Color Atlas of Pathophysiology © 2000 Thieme
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