Page 56 - Color Atlas Of Pathophysiology (S Silbernagl Et Al, Thieme 2000)

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B. Specific Immune Defense
T lymphocytes
+
+
CD8 type CD4 type
Presentation of antigen (identifies antigen in HLA I) (identifies antigen in HLA II)
by APC:
– macrophages
– dendritic cells
– B cells
APC Antigen T cell
HLA I T-cell receptor ‘Naive’
or HLA II T cell
Double signal
B7 CD28
1
e.g. ICAM LFA1
dendritic cell
IL-2
IL-2 receptor
Blood

3
T-cell proliferation
(clonal expansion and differentiation)
CD8/HLA I CD4/HLA II
Infected cell, T H2 cell
tumor cell, foreign cell Cytotoxic T cell T H1 cell
IL-10,
TGFβ
IFNγ

Infected T cell
cell ICAM LFA1
CD8
HLA I Macrophage
T-cell receptor
activation
Antigen
CD95 CD95 ligand 6
Apoptosis Perforins
H 2 O,NaCl Proteolysis
Granzyme B
2 Macrophage
46 Cytolysis Inflammation

Silbernagl/Lang, Color Atlas of Pathophysiology © 2000 Thieme
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