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Respiratory Alterations
         14               and Management







                          Maria Murphy
                          Sharon Wetzig
                          Judy Currey




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                                                              required  mechanical  ventilation;   a  statistic  of  41%  in
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            Learning objectives                               2008.  Failure or inadequate function of the respiratory
                                                              system occurs as a result of direct or indirect pathophysio-
            After reading this chapter, you should be able to:  logical conditions. The process of mechanical ventilation
            ●   describe the pathophysiological mechanisms of acute   may also injure a patient’s lungs, further impacting func-
               respiratory failure (ARF) and key principles of patient   tioning of the respiratory system. Preventing or minimis-
               management                                     ing  ventilator-associated  lung  injury  is  therefore  also  a
            ●   differentiate between hypoxaemic (type I) and   primary  goal  of  patient  care.  Chapter  13  described  the
               hypercapnoeic (type II) respiratory failure    relevant  anatomy  and  physiology  and  assessment  and
            ●   outline the incidence of respiratory alterations in the   monitoring  practices  for  a  patient  with  life-threatening
               Australasian critical care context             respiratory  dysfunctions.  This  chapter  describes  the
            ●   discuss the aetiology, pathophysiology, clinical   incidence,  pathophysiology,  clinical  manifestations  and
                                                              management of common respiratory disorders that result
               manifestations and management of common respiratory   in  acute  respiratory  failure,  specifically  pneumonia
               disorders managed in intensive care, specifically   (including discussion of respiratory epidemics), asthma,
               pneumonia, respiratory epidemics, asthma, chronic   chronic  obstructive  pulmonary  disease  (COPD),  acute
               obstructive pulmonary disease (COPD), acute lung injury   lung injury (ALI), pneumothorax and lung transplanta-
               (ALI) and pneumothorax                         tion. Discussion of oxygenation and ventilation strategies
            ●   describe the evidence base for key components of nursing   to support respiratory function during a critical illness is
               and collaborative practice involved in the management of   presented in Chapter 15.
               patients with ARF in ICU
            ●   outline the principles and immediate postoperative
               management for lung transplant recipients.     INCIDENCE OF RESPIRATORY
                                                              ALTERATIONS
                                                              Respiratory  diseases  are  common  and  affect  significant
                                                              numbers of the population in Australia, accounting for
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            Key words                                         almost half of all hospital admissions.  These diseases are
                                                              also the most common illness responsible for emergency
                                                              admission to hospital, the most common reason to visit
            acute respiratory failure                         a general practitioner and represent the most commonly
            acute respiratory distress syndrome               reported  long-term  illnesses  in  children.   Despite  these
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            hypoxaemic respiratory failure                    findings, the incidence of respiratory alterations is diffi-
            hypercapnoeic respiratory failure                 cult to quantify as the number of patients who require
            influenza                                         admission  to  hospital  as  a  result  of  respiratory  disease
            oxygenation                                       represent a small proportion of the total number affected.
            ventilator-associated pneumonia                   Further, patients who require admission to ICU as a result
                                                              of respiratory disease represent only a fraction of all hos-
                                                              pital admissions. 5,6
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         INTRODUCTION                                         Data presented in Table 14.1  illustrates the total number
                                                              of patients (adults and children) admitted to hospital as
         The  most  common  reason  that  patients  require  admis-  a result of a range of respiratory diseases. While it is dif-
         sion to an intensive care unit (ICU) is for support of their   ficult to determine the number of patients in each diag-
         respiratory system. Over the last decade, almost half of   nostic group who required admission to ICU as part of
     352 all patients admitted to ICU in Australia and New Zealand   their management, ICU admissions account for around
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