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404  P R I N C I P L E S   A N D   P R A C T I C E   O F   C R I T I C A L   C A R E

         and  extubation  readiness. 243-247   Recently,  coupling  of  a   difficulty. 260  These patients are most likely to benefit from
         sedation  and  weaning  protocol  was  found  to  result   an  individualised  and  structured  approach  to  weaning
         in  a  three-day  reduction  in  the  duration  of  ventilation   using progressive lengthening of tracheostomy trials with
         compared  to  standard  care  in  four  North  American   supportive ventilation in between in combination with
         hospitals. 248  A recent systematic review and meta-analysis   early physical therapy.
         of  11  weaning  protocol  trials  including  1971  patients
         demonstrated  a  reduction  in  the  duration  of  mechani-
         cal  ventilation. 249   However,  the  authors  cautioned  that
         the  effect  of  weaning  protocols  may  vary  according   Practice tip
         to  the  ICU  organisational  characteristics  such  as
         an  intensivist-led  ICU  model,  high  levels  of  physician   Tachypnoea and decreased tidal volumes during weaning are
         staffing,  structured  ward  rounds,  collaborative  discus-  clear indicators that a patient is not ready for extubation.
         sion  and  more  frequent  medical  review;  all  character-
         istics  reported  for  ICUs  in  Australia  and  New
         Zealand. 250,251                                     Complications of Mechanical Ventilation
                                                              Physiological complications associated with mechanical
         Automated weaning                                    ventilation  include  ventilator-associated  lung  injury
         Automated  computerised  systems  potentially  enable   (VALI) and nosocomial infection (VAP). 116,122  VALI occurs
         more  efficient  weaning  by  providing  improved  adapta-  through  alveolar  over-distension  and  cyclic  opening
         tion of ventilatory support through continuous monitor-  and  closing  of  alveoli  resulting  in  diffuse  alveolar
         ing  and  real-time  intervention. 252   One  such  system,   damage,  increased  permeability,  pulmonary  oedema,
         SmartCare™/PS,  monitors  three  respiratory  parameters,   cell  contraction  and  cytokine  production. 122,130,136,261-263
         frequency, V T  and end-tidal carbon dioxide (ETCO 2 ) con-  VAP  substantially  increases  the  duration  of  ICU  stay
         centration,  every  two  or  five  minutes  and  periodically   and  is  associated  with  an  attributable  mortality  of
         adapts  pressure  support  (PS). 252,253   SmartCare/PS  estab-  5.8–8.5%. 264-266   Additional  complications  associated
         lishes a respiratory status diagnosis, based on evaluation   with  mechanical  ventilation  are  listed  in  Table  15.8.
         of  the  three  parameters,  and  may  either  decrease  or   Complications  can  occur  due  to  inappropriate  applica-
         increase PS, or leave it unchanged to maintain the patient   tion of mechanical ventilation. This may result in extra-
         in  a  defined  ‘respiratory  zone  of  comfort’. 254,255   Once   alveolar  gas  causing  pneumothoraces  or  subcutaneous
         SmartCare/PS has successfully minimised the level of PS,   emphysema due to high peak inspiratory pressures, and
         a one-hour observation period occurs. For patients who   alveolar  stretch  and  oedema  formation  as  the  result  of
         remain within the respiratory zone of comfort through-  large  tidal  volumes. 68
         out the observation period, SmartCare/PS recommends
         to ‘consider separation’, indicating the patient’s respira-  SUMMARY
         tory  status  now  suggests  the  patient  will  tolerate
         extubation.                                          Support  of  oxygenation  and  ventilation  during  critical
                                                              illness are key activities for nurses in ICU. Oxygen therapy
         SmartCare/PS substantially reduced the duration of ven-  promotes aerobic metabolism but has adverse effects that
         tilation  and  ICU  length  of  stay  when  compared  to   need  to  be  considered.  Various  oxygen  delivery  devices
         physician-controlled  weaning  using  local  guidelines  in   provide low or variable flows of oxygen.
         five European ICUs. 256  These effects were not confirmed
         when the SmartCare/PS system was compared to weaning   Strong evidence supports the use of NIV for COPD and
         managed by experienced critical care nurses in a single   CHF,  but  caution  is  required  when  used  for  other
         Australian setting. 257                              diagnoses such as pneumonia. NIV success is dependent
                                                              on  patient  tolerance,  with  common  complications
                                                              including  pressure  ulcers,  conjunctival  irritations,  nasal
         The difficult-to-wean patient                        congestion,  insufflation  of  air  into  the  stomach  and
         International  reports  indicate  patients  that  require   claustrophobia.
         mechanical ventilation for ≥21 days account for less than
         10% of all mechanically-ventilated patients, but occupy   Airway support can be provided with oro- or nasopharyn-
         40% of ICU bed days and accrue 50% of ICU costs. 258,259    geal  airways,  laryngeal  mask  airways  and  endotracheal
         A  recommendation  from  the  National  Association  for   intubation; oral intubation is the preferred method. For
         Medical Direction of Respiratory Care (NAMDRC) states   a patient with an ETT, the key points for practice are:
         that prolonged mechanical ventilation should be defined   ●  ETT  placement  should  be  confirmed  with  end-tidal
         as  ‘≥21  consecutive  days  of  ventilation  required  for  ≥6   CO 2  monitoring
                      230
         hours per day’.  Prolonged weaning has been defined as   ●  the aim of endotracheal cuff management is to prevent
         greater than 7 days of weaning after the first SBT or more   airway  contamination  and  enable  positive  pressure
                        230
         than  three  SBTs.   Little  evidence  defines  the  optimal   ventilation
         method for managing the difficult-to-wean patient. One   ●  closed  suctioning  reduces  alveolar  derecruitment
         trial found no difference in weaning duration or success   compared to opening suctioning
         when comparing tracheostomy trials to low-level pressure   ●  instillation  of  normal  saline  is  not  recommended
         support  in  patients  with  COPD  experiencing  weaning   during routine tracheal suctioning.
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