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696  S P E C I A LT Y   P R A C T I C E   I N   C R I T I C A L   C A R E

         conti nuous  monitoring  of  heart  rate,  SvO 2   saturation,   vasopressors  are  recommended. 162   Inotropic  drugs  that
         quality of peripheral pulses, capillary refill, level of con-  are  recommended  in  children  include  dopamine,  adre-
         sciousness, peripheral skin temperature, urine output as   naline and noradrenaline. Vasodilators, including sodium
         indirect measures of cardiac output (CO) as well as serial   nitroprusside or nitroglycerin, are used to recruit micro-
         blood gas and electrolyte analysis. 162              circulation; type III phosphodiesterase inhibitors are used
                                                              to  improve  cardiac  contractility.  If  shock  persists  and
         Diagnosis  of  septic  shock  can  be  difficult  in  children.
         When  present,  non-blanching  rash  is  a  specific  sign  of   there  is  a  risk  for  adrenal  insufficiency,  hydrocortisone
                                                                                    162
         meningococcal septicaemia. 166                       therapy is recommended.   ECMO may also be consid-
                                                              ered for a child who appears to be developing irreversible
                                                              shock. 162
            Practice tip                                      Monitoring of blood glucose is essential in all critically
                                                              ill infants and children. In septic shock hyperglycaemia
            As rash may be less visible in dark-skinned children, check soles   may be present, which has been linked to higher mortal-
                                                                                               162
            of feet, palms of hands and conjunctivae in those children.  ity  rates  in  paediatric  septic  shock.   Blood  glucose
                                                              should  be  monitored  and  maintained  within  normal
                                                              ranges (80–150 mg/dL) with appropriate use of insulin
         However,  a  certain  proportion  of  children  will  present   and glucose administration. 104,162
         with non-specific symptoms or signs of infection, such as
         fever, vomiting, lethargy, irritability, or headache and the   THE CHILD EXPERIENCING ACUTE
         conditions  may  be  difficult  to  distinguish  from  other
         infections. 14,15,166  Laboratory testing of samples of blood,   NEUROLOGICAL DYSFUNCTION
         urine, stool, sputum, cerebrospinal fluid and any obvious   There are many reasons why an infant or child can present
         wounds  or  lesions  is  standard  practice  in  adults  and   with  an  acute  episode  of  neurological  dysfunction.
         children.                                            Common  presentations  to  an  ICU  include  meningi-
                                                              tis, 173,174  encephalitis, 174  seizures and encephalopathy 175-177
         MANAGEMENT OF SHOCK                                  (see also Chapter 17). Assessment and recognition of the
         Early  recognition  of  shock,  institution  of  appropriate   clinical features and management of the various causes
         goal-directed  therapy  and  targeting  the  causative  agent   of  neurological  dysfunction  in  children  are  the  keys  to
         remain  the  mainstay  of  managing  septic  shock  in  chil-  achieving good outcomes.
         dren as in adults. Goal-directed therapies such as oxygen
         therapy,  fluid  resuscitation,  maintenance  of  acceptable   NEUROLOGICAL ASSESSMENT
         blood pressure, and institution of pharmacological treat-  To assess a child’s level of consciousness, several different
         ment and other supportive treatments to achieve thera-  scales  can  be  used.  The  Glasgow  Coma  Scale  (GCS)  is
         peutic goals are practised in managing shock in children,   commonly  used, 178   but  the  Glasgow  Coma  Motor  sub-
         and are linked to better outcomes. 162,163
                                                              score is more appropriate for children. 179  Another reliable
         Large  amounts  of  fluid  may  be  required  by  children   scale  is  the  Full  Outline  of  Unresponsiveness  (FOUR)
                                                         16
         despite peripheral oedema or absence of overt fluid loss.    score; it includes four parameters (eye response, motor
         Early aggressive fluid resuscitation will improve survival   response, pupil reflexes, and breathing) rated on a 0 to 4
         in children with hypovolaemic and septic shock, particu-  scale,  giving  a  possible  score  situated  between  0  (com-
         larly if received within the first hour, when hypotension   pletely  unresponsive)  and  16. 180   The  FOUR  score  and
                             19
         has not yet developed.  Intravascular access in children   the GCS are both able to predict in-hospital morbidity
         can be difficult and umbilical venous access in newborns   and poor outcome at the end of hospitalisation.
         and intraosseous access in children can be used before   Other neurological assessment parameters include:
                                                          ®
         the placement of central lines. 162,167  The use of the EZ-IO
         (Vidacare  Corporations,  Texas)  paediatric  intraosseous   l  Pupils: assess size, reaction and symmetry.
         needle  set  and  driver  system  has  become  common  in   l  Posture: abnormal flexion posturing, often referred to
         practice. 168,169  Other kinds of manually inserted intraos-  as decorticate posturing, is a flexion response of the
         seous needles are available, and regardless of type, intraos-  arms with either flexion or extension of the legs, while
         seous needles all allow rapid access to the intramedullary   abnormal  extension  posturing,  often  referred  to  as
         capillary network, facilitating delivery of fluids, drugs and   decerebrate posturing, is an extension response of all
         blood products. The site of choice in infants and children   limbs,  where  arms  rotate  externally.  Both  abnormal
         is  the  proximal  tibia,  2–3 cm  below  the  tibial  tuberos-  flexion and extension posturing in a previously normal
            170
         ity.  Once sited, a syringe must be attached to aspirate   child may indicate raised intracranial pressure.
         and ascertain correct placement. Fluid boluses can then   l  Meningism:  this  is  indicated  by  neck  stiffness  in  a
         be given via syringe into the intramedullary space with   child and full/bulging fontanelle in an infant.
         the aim of restoring circulating volume which will in turn
         facilitate venous access with improvement of peripheral   SEIZURES
         perfusion. 171
                                                              Seizures are covered in Chapter 17. The various aetiolo-
         Similarly to adults, after appropriate volume resuscitation   gies of seizures in children include febrile convulsions,
         has been given and symptoms of shock are not resolving   CNS infection such as meningitis or encephalitis, meta-
         or  hypotension  is  developing,  then  inotropes  and    bolic imbalances, drugs, trauma or epilepsy. Seizures in
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