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694  S P E C I A LT Y   P R A C T I C E   I N   C R I T I C A L   C A R E

            applied negative pressure, as too much can result in   Non-invasive Ventilation
            atelectasis.                                      Non-invasive  ventilation  (NIV)  refers  to  ventilatory
         l  Restraints may be required to limit the movement of   support  without  an  artificial  airway  in  the  trachea  (see
            the child, with the aim of preventing accidental extu-  Chapter  15).  In  critically  ill  children  with  respiratory
            bation rather than maintaining the child in an immo-  failure, NIV may be used to reduce the need for intuba-
            bile  state.  Restraints  may  be  physical,  such  as  arm   tion.  However,  the  evidence  for  its  use  in  children  is
            boards  or  hand  ties;  or  chemical,  such  as  sedation.   weak 152   and  often  extrapolated  from  adults. 153   Some
            Accidental extubation is a medical emergency.
                                                              studies showed that NIV decreases the rate of ventilator-
         MODES OF VENTILATION                                 associated pneumonia and reduces oxygen requirement
                                                              in children with lower airway diseases when compared to
         There are many modes of ventilation (see Chapter 15 for   conventional ventilation 140,154  and may be recommended
         more details). This section includes information specifi-  as the first line ventilation strategy. 142
         cally related to paediatric ventilation. As with adults, arte-
         rial blood gases should be taken about 15–20 minutes   High-frequency Oscillatory Ventilation
         after initiating mechanical ventilation.
                                                              High-frequency  oscillatory  ventilation  (HFOV)  uses
         Volume Ventilation of Children                       supra-physiological  ventilatory  rates  and  tidal  volumes
         Typically, volume ventilation is not used in infants under   less  than  anatomical  dead  space  to  accomplish  gas
                                                              exchange.  Typical  ventilator  rates  are  3–15 Hz  or  180–
         5 kg  due  to  the  small  tidal  volumes,  which  risk  being   600 breaths/min (1 Hz = 60 breaths). HFOV is primarily
         lost  in  the  distensible  tubing  and  leaking  around  the   used in managing infants and children with diffuse alveo-
         ETT.  In  addition,  most  volume  ventilators  do  not  have   lar or interstitial disease requiring high peak distending
         a  constant  fresh  gas  flow,  so  the  infant  has  to  work   pressures.  Goals  include  maximising  alveolar  recruit-
         harder to trigger a breath. Some of the newer models of   ment,  minimising  barotrauma  and  providing  adequate
         ventilator have attempted to overcome these problems.   alveolar gas exchange.
         Steps in beginning volume ventilation for a child are as
         follows: 150                                         HFOV is delivered primarily by the Sensor Medics 3100A
                                                              (Mayo Healthcare Australia). This ventilator uses a dia-
            1.  Set the tidal volume at <8 mL/kg. This is a protec-  phragm piston unit to actively move gas into and out of
               tive lung strategy approach  and can be increased   the lung, and requires a non-compliant breathing circuit.
                                      151
               if needed.                                     A  major  difference  between  HFOV  and  other  forms  of
            2.  Set the rate at 20 breaths/min. This is lower than   ventilation is that there is active expiration with oscilla-
               physiological  norm  for  infants,  but  the  slightly   tion  versus  passive  expiration  for  conventional  ventila-
               larger tidal volumes will compensate.          tion. 150,155   Unlike  conventional  ventilation,  which  uses
            3.  Set the FiO 2  at <0.6 and titrate according to oxygen   bulk flow to deliver gas to the lungs, using smaller-than-
               saturation and blood gases.                    dead-space tidal volumes utilises the mechanisms of pen-
            4.  Set the PEEP at 5 cm. This is slightly higher than   delluft, Taylor dispersion, asymmetrical velocity profiles,
               physiological norm.                            cardiogenic  mixing  and,  to  a  very  limited  extent,  bulk
            5.  Set the trigger sensitive enough to allow the infant   flow. 155  These are all terms used to describe the distribu-
               or  child  to  trigger  a  breath  without  working  too   tion of gas when rapid rates and tiny volumes are used.
               hard.  If  a  continuous  fresh  gas  flow  is  available,
               then this is preferable. If autocycling occurs, gradu-  Ventilation is dependent on amplitude (a determinant of
               ally decrease the trigger-setting sensitivity until the   tidal  volume)  much  more  than  rate.  With  the  Sensor
               autocycling stops.                             Medics oscillator, paradoxically lowering frequency (Hz)
                                                              improves CO 2  removal. This is thought to occur because
         Pressure Ventilation of Children                     the  oscillating  diaphragm  is  able  to  move  through  a
         The pressure ventilation mode is most commonly used   greater distance, thus increasing tidal volume by provid-
                                                              ing more inspiratory time and a longer expiratory time.
                                                                                                             155
         in infants weighing under 5 kg or with children who have
         a large leak around the ETT. Steps in beginning pressure   The principal determinants of oxygenation are the same
         ventilation for a child are as follows and should be based   as those for conventional ventilation. Therefore, as with
         on arterial blood gases: 150                         conventional ventilation, the alveoli must be opened and
                                                              prevented  from  collapsing  if  hypoxaemia  is  to  be  cor-
            1.  Set  the  peak  inspiratory  pressure  (PIP)  at   rected.  HFOV  achieves  this  through  delivering  a  high
               18–20  cmH 2 O.                                mean  airway  pressure  without  imposing  a  large  tidal
            2.  Set the positive end expiratory pressure (PEEP) at   volume.  It thus avoids overdistension and the risk of
                                                                     150
               5 cmH 2 O.                                     barotrauma.
            3.  Set the rate at 20 breaths/min.
            4.  Set the FiO 2  at <0.6 and titrate according to oxygen
               saturation and blood gases.                    Extracorporeal Membrane Oxygenation
            5.  Set the trigger sensitive enough to trigger a breath.   Extracorporeal  membrane  oxygenation  (ECMO)  is  an
               Most pressure ventilators have a constant fresh gas   alternative  method  of  providing  ventilatory  and/or
               flow, which allows the child to breathe spontane-  cardiac  support.  When  used  to  support  ventilation,
               ously without increased effort.                ECMO     allows   the   lungs   to   rest   and   heal.
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