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728  S P E C I A LT Y   P R A C T I C E   I N   C R I T I C A L   C A R E

         the cardiovascular system in pregnancy is poorly tolerated   Treatment Priorities
         by some women and cardiac disease in pregnancy remains   All women with cardiac disease are considered to have a
         a leading cause of death in Australia. 52
                                                              ‘high risk’ pregnancy and should receive maternity care
         Rheumatic heart disease is the most frequently acquired   by  a  multidisciplinary  team  including  as  a  minimum,
                                                                                                              151
         heart disease and is a condition normally associated with   obstetrician,  midwife,  cardiologist  and  anaesthetist.
         developing  countries. 144   In  Australia,  rheumatic  heart   The timing and location of delivery, choice of anaesthesia
         disease is a significant concern in Aboriginals and Torres   and delivery mode should each be discussed by the team
         Strait Islanders with rates in Indigenous communities in   with the woman, and planned well in advance. If a preg-
         the  Northern  Territory  noted  to  be  the  highest  in  the   nant woman with cardiac disease is admitted to ICU, this
         world, and are over 30 times higher than non-Indigenous   multidisciplinary  team  should  be  consulted  about  her
                                                   ¯
         Australians. 145,146   Similarly  in  New  Zealand,  Maori  and   care. Priorities of care include:
         Pacific Islanders have a much higher incidence of rheu-  l  Pre-pregnancy  counselling:  this  should  allow  a  full
         matic  heart  disease  than  New  Zealanders  of  European   and  frank  discussion  about  the  likely  risks  of  preg-
         ancestry.  Refugee  and  immigrant  women  who  have    nancy  for  the  individual  and  to  discuss  a  treatment
         migrated  from  developing  countries  also  have  a  higher   path.  This  is  of  particular  importance  for  women
         risk for rheumatic heart disease in pregnancy. Rheumatic   who are on potentially teratogenic medication, such
         heart  disease  is  a  delayed  complication  of  acute  rheu-  as  warfarin,  and  for  women  who  may  benefit  from
         matic fever, and results from untreated Group A strepto-  surgery or interventional treatment prior to conceiv-
         coccus bacterial infection. It most commonly affects the   ing. Additionally, women with congenital heart disease
         mitral valve, though may also affect the aortic valve and   may require genetic counselling to determine the like-
         usually  involves  restricted  leaflet  mobility,  focal  or     lihood of congenital heart disease in any offspring.
         generalised valvular thickening and abnormal subvalvu-  l  Diagnosis:  standard  investigations  including  chest
         lar  thickening,  resulting  in  regurgitation  and,  rarely,   X-ray, ECG, CT scan and MRI should be attended to
         stenosis. 147
                                                                 as indicated by the clinical condition. In general, diag-
         A cardiac condition increasingly presenting in pregnancy   nostic imaging of a critically ill woman should not be
         is  acute  myocardial  infarction  (AMI),  thought  to  be   withheld  due  to  concerns  about  the  fetus,  with
         related  to  the  changing  demographics  of  the  pregnant   abdominal shielding used whenever possible. 152
         population, such as older women becoming pregnant. 148    l  Heart failure: as was outlined in the section on peri-
         AMI is the leading cardiac cause of maternal death in the   partum  cardiomyopathy,  the  principles  of  treatment
         UK,  mostly  related  to  undiagnosed  ischaemic  heart   for heart failure in pregnancy are the same as for the
                24
         disease.  Additionally, spontaneous aortic dissection and   non-pregnant population.
         coronary  artery  dissection  may  also  occur  in  pregnant   l  Arrhythmias: commonly used drugs including digoxin,
         women with no preexisting disease. 149  Signs and symp-  lignocaine, flecainide, verapamil, sotalol, propranolol,
         toms of heart failure and complaints of chest pain must   adenosine and amiodarone; although limited studies
         be investigated and not put down to the ‘minor discom-  exist in the pregnant population, all have been used
         forts’  of  pregnancy,  such  as  breathlessness,  heartburn,   safely  and  effectively  during  pregnancy. 153   Transient
         fatigue  and  dependent  oedema.  Given  that  the  cardiac   neonatal  hypothyroidism  has  been  described  in
         output is expected to increase 40–50% in a normal preg-  women on amiodarone and monitoring of neonatal
         nancy, any cardiac condition resulting in poor left ventric-  thyroid function is recommended. 154
         ular function and/or restricted left ventricular outflow are   l  Cardiac  surgery:  interventions  such  as  valvuloplasty
         particularly associated with poor outcomes in pregnancy.  may  be  required.  Open-heart  surgery  is  only  per-
                                                                 formed during pregnancy when the maternal condi-
         Also relevant for the outcome of both mother and baby     tion is critical, for example coronary artery dissection
         is  whether  any  valvular  disease  has  been  repaired  and   or  severe  dysfunctioning  valve,  because  of  the  high
         whether a tissue or mechanical valve has been inserted.   chance of fetal loss associated with the woman going
         Use  of  anticoagulants  is  of  particular  concern  during   on  bypass.  Standard  care  should  be  provided  to  a
         pregnancy, with warfarin contraindicated for use in preg-  pregnant  woman,  with  care  to  nurse  the  woman
         nancy. However, the risk of thrombosis is relatively high   ≥20 weeks’ gestation with a 15 degree left lateral tilt
         in pregnant women and some women remain on warfa-       if possible, to reduce the negative effects of aorto-caval
         rin despite the risk of associated congenital anomaly and   compression.  Open-heart  surgery  and  ECMO  have
         the increased likelihood of miscarriage. 150
                                                                 been used successfully in pregnant women with good
                                                                 outcomes for mother and baby. 155,156
                                                              l  Thrombus prevention: this is a priority in women with
            Practice tip                                         valvular disease/prosthetic valves, atrial fibrillation or
                                                                 dilated heart chambers at risk of thrombus formation,
            Congenital  and  acquired  cardiac  disease  can  present  for  the   especially because of the normal hypercoagulopathy
            first  time  during  pregnancy,  unmasked  by  the  additional     associated  with  pregnancy.  Warfarin  embryopathy,  a
            phy siological requirements of pregnancy. Women with known   recognised  collection  of  developmental  anomalies
            preexisting  disease  may  experience  unpredictable  deteriora-  such  as  nasal  hypoplasia  and  epiphysis  stippling,  is
            tion in cardiac function.                            associated with warfarin use in the first trimester, con-
                                                                 sequently  warfarin  use  is  contraindicated.  However,
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