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758  S P E C I A LT Y   P R A C T I C E   I N   C R I T I C A L   C A R E

         retrieval.  Death  is  determined  by  cessation  of  circula-  with  eye  caps. 77,78   Support  requirements  for  families  of
         tion, with recommendations that the ECG is not moni-  tissue-only  donors  share  many  aspects  of  programs
         tored  (electrical  activity  can  persist  for  many  minutes   provided for families of multi-organ donors. A sensitive
         following  cessation  of  circulation),  but  an  arterial  line   approach,  provision  of  adequate  information  to  assist
         is  used  to  determine  the  time  of  cessation  of  circula-  informed  decision  making,  offers  of  bereavement
             13
         tion.   If  withdrawal  occurs  in  critical  care,  an  intraab-  counselling  and  follow-up  information  of  recipient
         dominal catheter may be inserted via the femoral artery   outcomes  are  evidence-based  strategies  of  successful
         after  cardiac  standstill  to  infuse  cold  perfusion  fluid   programs. 1,79
         into the abdominal cavity. If the lungs are to be retrieved,
         perfusion  fluid  is  infused  via  bilateral  intercostal  cath-
              69
         eters.   The  patient  is  then  transferred  to  theatre  for   SUMMARY
         organ  retrieval.  When  withdrawal  of  treatment  occurs
         in  theatre,  a  catheter  is  not  required  and  retrieval  may   Australia  and  New  Zealand  have  an  opt-in  system  of
         commence  after  the  patient  is  declared  deceased  (ces-  giving consent for organ and tissue donation. After death
         sation  of  circulation  for  greater  than  two  minutes).  If   has  been  confirmed,  the  option  of  organ  and  tissue
         the  patient  does  not  die  during  the  window  of  time   donation  is  given  to  the  next  of  kin,  or  information
         available  for  organ  retrieval,  they  are  transferred  back   from a consent indicator database is sought to determine
         to  ICU. 74                                          the wishes of the person. Each person is assessed on a
                                                              case-by-case  basis  to  determine  medical  suitability  for
                                                              organ  and  tissue  retrieval  for  transplant.  The  treating
         TISSUE-ONLY DONOR                                    clinicians  are  not  expected  to  make  this  decision  and
                                                              their involvement and care is vital. Support and informa-
         People  confirmed  as  dead  using  cardiac  criteria  can  be
         tissue  donors.  Eyes  (whole  and  corneal  button)  are   tion  is  available  around  the  clock  from  the  respective
         retrieved  for  cornea  and  sclera  transplant.  Musculo-  donor  agencies  and  tissue  banks.  Donor  family  care
         skeletal tissue is used for bone grafting (long bones of    commences at the time of the family member’s admis-
         arms and legs, hemipelvis), urology procedures and treat-  sion and continues as required with structured bereave-
         ment  of  sport  injuries  (ligaments,  tendons,  fascia  and   ment programs specific to donor family care. In Australia
         meniscus). Heart valves (bicuspid, tricuspid valves, aortic   and  New  Zealand,  consent  to  be  an  organ  and  tissue
         and pulmonary tissue) are used for heart valve replace-  donor can be indicated by people when alive or by the
         ment and cardiac reconstruction. Skin (retrieved from the    next  of  kin  after  death.
         lower  back  and  buttocks)  is  used  for  the  treatment  of   There are three ‘types’ of organ or tissue donor:
         burns. 75
                                                                 1.  multiorgan and tissue donor: after brain death has
                                                                    been confirmed
         IDENTIFICATION OF POTENTIAL                             2.  donor  after  cardiac  death:  controlled  withdrawal
         TISSUE-ONLY DONOR                                          of treatment in critical care/operating suite
         The  most  influential  aspect  for  tissue  donation  is  early   3.  tissue-only donor: after cardiac death.
         notification of the potential donor’s death to the relevant   Four factors directly influence the number of multiorgan
         tissue bank, ideally within hours of the person’s death.   donations:
         All deceased persons can be considered potential donors,
         with assessment for clinical suitability on a case-by-case   1.  incidence of brain death
         basis. As noted earlier, there is no expectation that treat-  2.  identification of potential donors
         ing clinicians will be required to make that decision or   3.  brain  death  confirmation  and  informed  consent
         make the approach to the next of kin. In general, once     for donation
         the death notification has been received, the determining   4.  donor management after brain death.
         factors are age, cause of death, time elapsed since death,   There is evidence in the literature to address and guide
         virology  results,  and  presence  of  infection.  The  legal   each factor, but each needs to be approached on a case-
         requirements of the consent-seeking process mirror those   by-case basis:
         of the multiorgan donor.
                                                              l  Medical  suitability  for  every  potential  donor  is
         After  checking  medical  suitability  and  the  relevant   asse ssed  individually  at  the  time  of  the  person’s
         consent indicator database, a coordinator from the tissue   death.
         bank  or  other  trained  personnel  approach  the  next    l  Support and guidance from donor agencies and tissue
         of  kin  with  the  option  of  tissue  retrieval.  Eyes  can  be   banks in Australia and New Zealand are available at
         retrieved  up  to  12  hours,  and  heart  valves,  skin  and   all times.
         bone  up  to  24  hours  after  death.  Of  note,  eye  donors   l  Care and support of the potential and actual donor
         can  be  up  to  99  years  old,  donors  of  heart  valve  up   family  is  a  high  priority  for  all  donor  agencies  and
                                                         76
         to 60 years and musculo skeletal up to 90 years of age.    tissue banks in Australia and New Zealand.
         After  tissue  retrieval,  every  effort  is  made  to  restore   l  Regular,  routine  follow-up  and  debriefing  oppor-
         anatomical appearance. Wounds are sutured closed and    tunities  for  critical  care  and  operating  theatre  staff
         covered  with  surgical  dressings,  limbs  given  back  their   are  important  to  manage  stress  reactions  or  other
         form, and eye shape is restored with the lids kept closed   concerns.
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