Page 300 - Concise Pathology for Exam Preparation ( PDFDrive )

12

Haematology

Normal Sequence of Development of Cells of Haematopoietic System (Flowchart 12.1)

Pluripotent haematopoietic cell
CFU-GEMM
C o m m o n m e t s d i o l e y m l l e c C o m m o y l n m p h e t s d i o m l l e c

CFU-GM CFU-Eo CFU-E &
CFU-Meg
Granulocytic monocytic Eosinophiloblast Erythrocyte- Pro-B Pro-T
stem cell megakaryocytic cell cell
stem cell
Eosinophil
Early Early
B cell thymocyte
Myeloblast Monoblast
Pronormoblast Megakaryoblast
Pre-B Common
Promyelocyte Promonocyte cell thymocyte
Early Promega-
(basophilic karyocyte
Myelocyte Monocyte normoblast) B cell Mature
Megakaryocyte T cell
Metamyelocyte Intermediate Plasma
(polychromatic) cell
normoblast Platelet
Stab form
Late
Neutrophil (orthochromatic)
normoblast

Reticulocyte

Erythrocyte
FLOWCHART 12.1. Normal development of cells of Haematopoietic system.

Normal reference haematological values are listed in Table 12.1.

TABLE 12.1. Normal haematological values

Haemoglobin (Hb) Adult male: 155 6 25 g/L
Adult female: 140 6 25 g/L
Mean corpuscular volume (MCV) 86 6 10 fL
Mean corpuscular haemoglobin (MCH) 29.5 6 2.5 pg
MCH concentration (MCHC) 325 6 25 g/L
RBC diameter 6.7–7.7 microns
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